QuickView for Lrp1 (gene)

Gene Symbol:

LRP1 Homo sapiens

Full name:

LDL receptor related protein 1

Synonyms:

A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5, prolow-density lipoprotein receptor-related protein 1, TbetaR-V/LRP-1/IGFBP-3 receptor, alpha-2-macroglobulin receptor, apolipoprotein E receptor, low density lipoprotein receptor-related protein 1, type V tgf-beta receptor

Genomic Location:

Chr 12: 55808549-55893409

Description:

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, a...

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This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  RTAAACA_FREAC2_01 ,  GTATTAT_MIR3693P ,  SMTTTTGT_UNKNOWN ,  TGANTCA_AP1_C ,  GATA1_01 ,  MZF1_01 ,  ZIC1_01 ,  P53_DECAMER_Q2 ,  VDR_Q3 ,  TGANNYRGCA_TCF11MAFG_01 ,  GATA3_01 ,  AP3_Q6 ,  EVI1_04 ,  ZIC3_01 ,  AP2ALPHA_01 ,  HNF4_DR1_Q3 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  TFIII_Q6 ,  RGAANNTTC_HSF1_01 ,  CEBPB_01 ,  CACCCBINDINGFACTOR_Q6 ,  E2F1_Q6_01 ,  RREB1_01 ,  ATF_01 ,  DR1_Q3 ,  AP4_01 ,  TGCGCANK_UNKNOWN ,  ATGCTGC_MIR103_MIR107 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  CCCNNGGGAR_OLF1_01 ,  NKX25_02 ,  TAATAAT_MIR126 ,  NRF2_Q4 ,  NRF1_Q6 ,  GATA2_01 ,  AR_Q2 ,  RNGTGGGC_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK2_01 ,  RTTTNNNYTGGM_UNKNOWN ,  IK1_01 ,  COUP_DR1_Q6 ,  ZIC2_01 ,  GTGGGTGK_UNKNOWN ,  CCANNAGRKGGC_UNKNOWN ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  FOXM1_01 ,  SRY_02 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  PPAR_DR1_Q2 ,  TGACATY_UNKNOWN ,  ATGAAGG_MIR205 ,  NFKB_Q6 ,  HNF4_01_B ,  PAX4_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

12q13.3

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