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QuickView for Lymphotoxin alpha (gene)


Gene Symbol:
LTA Homo sapiens Homo sapiens
Full name:
lymphotoxin alpha
Synonyms:
LT, TNFB, TNFSF1, TNLG1E, lymphotoxin-alpha, LT-alpha, TNF superfamily, member 1, TNF-beta, truncated lymphotoxin alpha, tumor necrosis factor beta, tumor necrosis factor ligand 1E, tumor necrosis factor ligand superfamily member 1
Genomic Location:
Chr 6: 31648072-31650077
Description:
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses,...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6p21.33





GO Molecular Function

signaling receptor binding | cytokine receptor binding | molecular function regulator | tumor necrosis factor receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | tumor necrosis factor receptor superfamily binding

GO Biological Process

positive regulation of immune response | response to extracellular stimulus | response to nutrient levels | response to cytokine | regulation of neurogenesis | response to lipopolysaccharide | positive regulation of apoptotic process | regulation of cell development | regulation of programmed cell death | defense response to other organism | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | cellular response to tumor necrosis factor | cell differentiation | negative regulation of growth of symbiont involved in interaction with host | defense response | nervous system development | response to drug | neurogenesis | generation of neurons | cellular process | positive regulation of humoral immune response mediated by circulating immunoglobulin | positive regulation of immune effector process | positive regulation of adaptive immune response | immune system development | response to hypoxia | regulation of cell differentiation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | positive regulation of interferon-gamma production | positive regulation of chronic inflammatory response to antigenic stimulus | response to stimulus | positive regulation of immune system process | response to stress | regulation of cell proliferation | regulation of humoral immune response mediated by circulating immunoglobulin | regulation of humoral immune response | programmed cell death | response to molecule of bacterial origin | positive regulation of gliogenesis | cell-cell signaling | molecular function regulator | apoptotic process | response to external biotic stimulus | system development | response to oxygen levels | regulation of signal transduction | negative regulation of growth | multicellular organism development | positive regulation of inflammatory response | response to lipid | cytokine-mediated signaling pathway | positive regulation of humoral immune response | response to nutrient | positive regulation of cell differentiation | cellular response to cytokine stimulus | positive regulation of immunoglobulin mediated immune response | response to bacterium | cell communication | humoral immune response | regulation of glial cell proliferation | defense response to bacterium | positive regulation of cell proliferation | positive regulation of glial cell proliferation | lymph node development | regulation of signaling receptor activity | receptor regulator activity | regulation of fibroblast proliferation | regulation of growth | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of chronic inflammatory response | positive regulation of cell development | negative regulation of growth of symbiont in host | regulation of adaptive immune response | positive regulation of inflammatory response to antigenic stimulus | positive regulation of cell death | receptor ligand activity | immune response | cytokine activity | cell death | animal organ development | positive regulation of programmed cell death | tumor necrosis factor-mediated signaling pathway | positive regulation of cytokine production | positive regulation of chronic inflammatory response | defense response to Gram-positive bacterium | regulation of cell communication | regulation of gliogenesis | signaling | negative regulation of fibroblast proliferation | regulation of cytokine production | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of cell proliferation | regulation of interferon-gamma production | immune system process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | regulation of inflammatory response | response to other organism | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

cell | plasma membrane | extracellular region | extracellular space | cell periphery | membrane