QuickView for M6PR (gene)

Gene Symbol:

M6PR Homo sapiens

Full name:

mannose-6-phosphate receptor, cation dependent

Synonyms:

CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR, cation-dependent mannose-6-phosphate receptor, 46-kDa mannose 6-phosphate receptor, CD Man-6-P receptor, Mr 46,000 Man6PR, small mannose 6-phosphate receptor

Genomic Location:

Chr 12: 8984231-8993519

Description:

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced tr...

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This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  GAGCCTG_MIR484 ,  RYTTCCTG_ETS2_B ,  HOXA4_Q2 ,  NFY_C ,  AREB6_04 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  GGGAGGRR_MAZ_Q6 ,  LFA1_Q6 ,  CTCAGGG_MIR125B_MIR125A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ACCAAAG_MIR9 ,  NFY_01 ,  ACTAYRNNNCCCR_UNKNOWN ,  NFY_Q6 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

12p13.31

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