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QuickView for MAD2L1 (gene)


Gene Symbol:
MAD2L1 Homo sapiens Homo sapiens
Full name:
mitotic arrest deficient 2 like 1
Synonyms:
HSMAD2, MAD2, mitotic spindle assembly checkpoint protein MAD2A, MAD2 (mitotic arrest deficient, yeast, homolog)-like 1, MAD2 mitotic arrest deficient-like 1, MAD2-like protein 1, mitotic arrest deficient 2-like protein 1, mitotic arrest deficient, yeast, homolog-like 1
Genomic Location:
Chr 4: 121200037-121207411
Description:
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 4
4q27


Transcripts Names
NM_002358
Protein Names
Q548X9
Q13257
Q53F56
Q6IRW7



GO Molecular Function

identical protein binding | protein binding | protein homodimerization activity | protein dimerization activity

GO Biological Process

regulation of cell cycle process | proteolysis | regulation of programmed cell death | negative regulation of cellular process | regulation of organelle organization | regulation of chromosome segregation | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of ubiquitin-protein transferase activity | regulation of mitotic nuclear division | regulation of chromosome separation | negative regulation of chromosome segregation | negative regulation of apoptotic process | regulation of cell cycle | negative regulation of cellular metabolic process | negative regulation of mitotic metaphase/anaphase transition | spindle checkpoint | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of ubiquitin-protein transferase activity | catabolic process | regulation of mitotic cell cycle spindle assembly checkpoint | cellular component organization | regulation of mitotic cell cycle phase transition | chromosome segregation | regulation of protein ubiquitination | anaphase-promoting complex-dependent catabolic process | regulation of cell cycle phase transition | cellular protein catabolic process | proteasomal protein catabolic process | negative regulation of metabolic process | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | negative regulation of catalytic activity | sister chromatid segregation | regulation of catalytic activity | positive regulation of cell cycle | positive regulation of mitotic cell cycle | cell cycle | protein catabolic process | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | negative regulation of mitotic nuclear division | positive regulation of cell cycle checkpoint | cell division | regulation of cellular protein metabolic process | negative regulation of ubiquitin protein ligase activity | mitotic spindle assembly checkpoint | nuclear chromosome segregation | regulation of cellular metabolic process | negative regulation of mitotic sister chromatid segregation | regulation of protein metabolic process | negative regulation of mitotic sister chromatid separation | negative regulation of protein ubiquitination | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | protein metabolic process | cellular macromolecule catabolic process | regulation of sister chromatid segregation | mitotic cell cycle | nuclear division | metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | organic substance metabolic process | negative regulation of cellular protein metabolic process | regulation of chromosome organization | mitotic nuclear division | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of mitotic sister chromatid segregation | negative regulation of chromosome organization | negative regulation of molecular function | cellular protein metabolic process | organelle organization | positive regulation of cell cycle process | regulation of mitotic metaphase/anaphase transition | chromosome organization | positive regulation of mitotic cell cycle spindle assembly checkpoint | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | modification-dependent protein catabolic process | cell cycle checkpoint | negative regulation of cell death | mitotic sister chromatid segregation | regulation of cellular component organization | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | cytoplasm | spindle | intracellular organelle | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | condensed chromosome kinetochore | perinuclear region of cytoplasm | microtubule cytoskeleton | spindle pole | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear pore | cytosol | cytoskeleton | intracellular | mitotic spindle | condensed chromosome