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QuickView for MAG (gene)


Gene Symbol:
MAG Homo sapiens Homo sapiens
Full name:
myelin associated glycoprotein
Synonyms:
GMA, S-MAG, SIGLEC-4A, SIGLEC4A, SPG75, myelin-associated glycoprotein, sialic acid binding Ig-like lectin 4A, sialic acid-binding immunoglobulin-like lectin 4A
Genomic Location:
Chr 19: 40474878-40496547
Description:
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19q13.12


Transcripts Names
NM_002361
NM_080600
NM_001199216
Protein Names
Q53ES7
F5GYC0
P20916
Q567S4



GO Molecular Function

kinase binding | ceramide binding | ganglioside GT1b binding | protein kinase binding | ganglioside binding | carboxylic acid binding | enzyme binding | lipid binding | signaling receptor binding | sialic acid binding | carbohydrate derivative binding | anion binding | glycolipid binding | amide binding | identical protein binding | sphingolipid binding | ion binding | carbohydrate binding | protein binding | protein homodimerization activity | glycosphingolipid binding | protein dimerization activity | organic acid binding | small molecule binding

GO Biological Process

cell motility | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cell development | regulation of programmed cell death | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | nervous system development | neurogenesis | generation of neurons | regulation of neuron death | positive regulation of neurological system process | cellular process | negative regulation of axonogenesis | localization | axon ensheathment | negative regulation of developmental growth | negative regulation of apoptotic process | regulation of neuron projection development | central nervous system myelination | regulation of neurological system process | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | gliogenesis | cellular component organization | positive regulation of myelination | negative regulation of cell morphogenesis involved in differentiation | response to stimulus | cellular response to mechanical stimulus | oligodendrocyte development | negative regulation of neuron projection development | ensheathment of neurons | axon ensheathment in central nervous system | positive regulation of gliogenesis | regulation of cellular component size | regulation of axon extension | leukocyte migration | locomotion | negative regulation of neuron apoptotic process | system development | negative regulation of growth | myelination | multicellular organism development | cell migration | regulation of axonogenesis | regulation of neuron differentiation | regulation of myelination | positive regulation of cell differentiation | glial cell differentiation | regulation of neuron apoptotic process | negative regulation of cell growth | regulation of cell morphogenesis involved in differentiation | regulation of growth | negative regulation of cell projection organization | response to mechanical stimulus | anatomical structure development | positive regulation of neurogenesis | positive regulation of cell development | negative regulation of programmed cell death | oligodendrocyte differentiation | positive regulation of glial cell differentiation | negative regulation of axon extension | cell adhesion | negative regulation of neuron differentiation | positive regulation of astrocyte differentiation | cell-cell adhesion | regulation of glial cell differentiation | regulation of gliogenesis | glial cell development | cell development | regulation of developmental growth | regulation of cell size | regulation of nervous system development | regulation of developmental process | developmental process | regulation of cell growth | central nervous system development | cell-cell adhesion via plasma-membrane adhesion molecules | regulation of cell projection organization | immune system process | regulation of astrocyte differentiation | regulation of cell death | negative regulation of cell death | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

integral component of membrane | myelin sheath adaxonal region | neuron projection | paranode region of axon | cell | intrinsic component of membrane | compact myelin | cytoplasm | membrane microdomain | main axon | mesaxon | cell projection | plasma membrane | membrane raft | integral component of plasma membrane | cell periphery | axon | Schmidt-Lanterman incisure | intracellular | myelin sheath | membrane | intrinsic component of plasma membrane