QuickView for MALT1 (gene)
- Gene Symbol:
- MALT1
Homo sapiens - Full name:
- MALT1 paracaspase
- Synonyms:
- IMD12, MLT, MLT1, PCASP1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT lymphoma-associated translocation, MALT1 protease, caspase-like protein, mucosa associated lymphoid tissue lymphoma translocation gene 1, paracaspase, paracaspase-1
- Genomic Location:
- Chr 18: 54489598-54568350
- Description:
-
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. T...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
18q21.32
GO Molecular Function
protein self-association | enzyme activator activity | kinase regulator activity | enzyme binding | hydrolase activity | cysteine-type peptidase activity | molecular function regulator | catalytic activity | ubiquitin-like protein transferase activity | identical protein binding | cysteine-type endopeptidase activity | protein binding | kinase activator activity | ubiquitin-protein transferase activity | transferase activity | endopeptidase activity | enzyme regulator activity | protease binding | peptidase activity
GO Biological Process
positive regulation of immune response | regulation of T cell mediated immunity | immune response-regulating signaling pathway | intracellular signal transduction | enzyme activator activity | nuclear export | proteolysis | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | regulation of T-helper 17 type immune response | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | B cell differentiation | innate immune response activating cell surface receptor signaling pathway | intracellular transport | positive regulation of T cell differentiation | innate immune response-activating signal transduction | cellular process | lymphocyte differentiation | localization | positive regulation of immune effector process | kinase regulator activity | positive regulation of adaptive immune response | positive regulation of T-helper 17 cell differentiation | immune system development | positive regulation of protein kinase activity | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | regulation of T cell receptor signaling pathway | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | positive regulation of T cell cytokine production | cellular component organization | T cell activation | response to stimulus | positive regulation of NIK/NF-kappaB signaling | B-1 B cell differentiation | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of CD4-positive, alpha-beta T cell activation | mononuclear cell proliferation | response to stress | mature B cell differentiation | regulation of protein ubiquitination | positive regulation of cell-cell adhesion | positive regulation of cell activation | activation of innate immune response | cellular localization | response to molecule of bacterial origin | positive regulation of T cell activation | immune response-activating signal transduction | hemopoiesis | cellular component assembly | protein modification process | regulation of cell adhesion | macromolecule modification | cysteine-type peptidase activity | activation of protein kinase activity | molecular function regulator | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | positive regulation of lymphocyte differentiation | protein complex oligomerization | regulation of catalytic activity | regulation of phosphorylation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | positive regulation of intracellular signal transduction | regulation of T-helper 17 cell differentiation | Fc-epsilon receptor signaling pathway | positive regulation of cell differentiation | regulation of T cell cytokine production | B cell activation | cell proliferation | leukocyte proliferation | regulation of cellular protein metabolic process | activation of NF-kappaB-inducing kinase activity | response to bacterium | response to fungus | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of alpha-beta T cell differentiation | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | cysteine-type endopeptidase activity | regulation of RNA metabolic process | lymphocyte activation | positive regulation of molecular function | protein-containing complex assembly | activation of immune response | protein metabolic process | positive regulation of T-helper cell differentiation | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | protein ubiquitination | regulation of hemopoiesis | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | kinase activator activity | cell surface receptor signaling pathway | metabolic process | ubiquitin-protein transferase activity | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | immune response | organic substance metabolic process | nuclear transport | animal organ development | T cell proliferation | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | regulation of T-helper cell differentiation | lymphocyte proliferation | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | endopeptidase activity | positive regulation of CD4-positive, alpha-beta T cell differentiation | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | response to biotic stimulus | nucleocytoplasmic transport | regulation of developmental process | developmental process | positive regulation of alpha-beta T cell activation | Fc receptor signaling pathway | cellular protein modification process | positive regulation of interleukin-2 production | regulation of cell-cell adhesion | innate immune response | positive regulation of T-helper 17 type immune response | stimulatory C-type lectin receptor signaling pathway | NIK/NF-kappaB signaling | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | peptidase activity | regulation of cell death | positive regulation of CD4-positive, alpha-beta T cell activation | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | fibrillar center | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | CBM complex
