QuickView for MAP4K3;jsessionid=32F60958802AF92797D0D598E563EAF6 (gene)
- Gene Symbol:
- MAP4K3
Homo sapiens - Full name:
- mitogen-activated protein kinase kinase kinase kinase 3
- Synonyms:
- GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1, mitogen-activated protein kinase kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, germinal center kinase-like kinase, germinal center kinase-related protein kinase
- Genomic Location:
- Chr 2: 39329926-39517723
- Description:
-
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-186 , Predicted Gene Targets for miR-196 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-324-5p , Predicted Gene Targets for miR-338 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-203
- Cytogenetic Map:
-
2p22.1
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | MAP kinase kinase kinase kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
response to radiation | response to cytokine | intracellular signal transduction | regulation of MAP kinase activity | positive regulation of phosphate metabolic process | cellular process | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | MAPK cascade | response to UV | response to stimulus | JNK cascade | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | activation of MAPKKK activity | protein serine/threonine kinase activity | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | response to light stimulus | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | positive regulation of molecular function | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | protein kinase activity | organic substance metabolic process | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | regulation of cell communication | signaling | positive regulation of phosphorylation | cellular protein metabolic process | positive regulation of MAP kinase activity | kinase activity | cellular protein modification process | MAP kinase kinase kinase kinase activity | positive regulation of metabolic process | cellular metabolic process | response to tumor necrosis factor | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
