QuickView for MAPK7;jsessionid=6D3E08C58BAFEDA659A1F338CEF9EC38 (gene)

Gene Symbol:

MAPK7 Homo sapiens

Full name:

mitogen-activated protein kinase 7

Synonyms:

BMK1, ERK4, ERK5, PRKM7, mitogen-activated protein kinase 7, BMK-1, BMK1 kinase, ERK-5, MAP kinase 7, MAPK 7, big MAP kinase 1, extracellular-signal-regulated kinase 5

Genomic Location:

Chr 17: 19221659-19227445

Description:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein...

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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  GGGAGGRR_MAZ_Q6 ,  CCTGTGA_MIR513 ,  NFY_Q6_01 ,  GGGCGGR_SP1_Q6 ,  GTGCCTT_MIR506 ,  CTGAGCC_MIR24 ,  CTGCAGY_UNKNOWN ,  RCGCANGCGY_NRF1_Q6 ,  SP1_Q6_01 ,  TCATCTC_MIR143

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

miRNA binding sites
(Source: miRecords):

hsa-miR-143 Targeted Genes ,  [miR-143] Targeted Genes

Cytogenetic Map:

17p11.2

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