QuickView for MARCH5;jsessionid=E67F4C55E6E512A8622682D946C6AAEB (gene)

Gene Symbol:

MARCH5 Homo sapiens

Full name:

membrane associated ring-CH-type finger 5

Synonyms:

MARCH-V, MITOL, RNF153, E3 ubiquitin-protein ligase MARCH5, RING-type E3 ubiquitin transferase MARCH5, membrane associated ring finger 5, membrane-associated RING finger protein 5, membrane-associated RING-CH protein V, membrane-associated ring finger (C3HC4) 5, mitochondrial ubiquitin ligase, ring finger protein 153

Genomic Location:

Chr 10: 94040900-94103701

Description:

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  RTAAACA_FREAC2_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTANTCA_UNKNOWN ,  ZIC1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AAAYWAACM_HFH4_01 ,  SRY_01 ,  E2A_Q2 ,  CAGGTG_E12_Q6 ,  TNCATNTCCYR_UNKNOWN ,  AP4_Q6 ,  AP2_Q6_01 ,  SP3_Q3 ,  GCAAAAA_MIR129 ,  ACTGCCT_MIR34B ,  ACTAYRNNNCCCR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  GFI1_01 ,  TTGTTT_FOXO4_01 ,  CAGCTG_AP4_Q5 ,  ER_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

10q23.32-q23.33

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