QuickView for MARCH6;jsessionid=546F649770729EDEECC87F580F6DE192 (gene)

Gene Symbol:

MARCH6 Homo sapiens

Full name:

membrane associated ring-CH-type finger 6

Synonyms:

DOA10, MARCH-VI, RNF176, TEB4, E3 ubiquitin-protein ligase MARCH6, RING finger protein 176, RING-type E3 ubiquitin transferase MARCH6, doa10 homolog, membrane associated ring finger 6, membrane-associated RING finger protein 6, membrane-associated RING-CH finger protein 6, membrane-associated RING-CH protein VI, membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase

Genomic Location:

Chr 5: 10406828-10488491

Description:

This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gen...

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This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGGAARNGGCNG_UNKNOWN ,  ATF4_Q2 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ACTTTAT_MIR1425P ,  CREB_Q4 ,  GGGAGGRR_MAZ_Q6 ,  CREBP1_Q2 ,  TTGGAGA_MIR5155P_MIR519E ,  GTGACGY_E4F1_Q6 ,  LFA1_Q6 ,  FREAC3_01 ,  AP1FJ_Q2 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  ACTGCCT_MIR34B ,  E4F1_Q6 ,  HSF_Q6 ,  YCATTAA_UNKNOWN ,  AP2_Q6 ,  CCTGCTG_MIR214 ,  CREB_Q2 ,  CTTTGT_LEF1_Q2 ,  CREB_Q2_01 ,  AGGAAGC_MIR5163P ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

5p15.2

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