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QuickView for MARS (gene)


Gene Symbol:
MARS Homo sapiens Homo sapiens
Full name:
methionyl-tRNA synthetase
Synonyms:
CMT2U, ILFS2, ILLD, METRS, MRS, MTRNS, SPG70, methionine--tRNA ligase, cytoplasmic, cytosolic methionyl-tRNA synthetase
Genomic Location:
Chr 12: 56168118-56196700
Description:
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q13.3





GO Molecular Function

methionine-tRNA ligase activity | nucleic acid binding | ribonucleotide binding | tRNA binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | aminoacyl-tRNA ligase activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | ligase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | response to nutrient levels | cellular response to platelet-derived growth factor stimulus | regulation of transcription by RNA polymerase I | response to hormone | tRNA aminoacylation | cellular response to extracellular stimulus | positive regulation of cellular biosynthetic process | cellular process | cellular response to starvation | response to growth factor | positive regulation of nitrogen compound metabolic process | response to peptide hormone | cellular amino acid metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | response to stimulus | peptide biosynthetic process | methionyl-tRNA aminoacylation | response to stress | cellular nitrogen compound biosynthetic process | response to peptide | response to starvation | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | cellular response to nutrient levels | nitrogen compound metabolic process | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | ncRNA transcription | regulation of gene expression | cellular response to stress | cellular response to peptide | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | cellular amide metabolic process | tRNA aminoacylation for protein translation | rRNA transcription | translation | response to platelet-derived growth factor | biosynthetic process | aromatic compound biosynthetic process | rRNA metabolic process | cell communication | regulation of cellular metabolic process | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I | peptide metabolic process | regulation of RNA metabolic process | carboxylic acid metabolic process | tRNA metabolic process | cellular response to epidermal growth factor stimulus | protein metabolic process | response to organic substance | response to insulin | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | amide biosynthetic process | positive regulation of transcription by RNA polymerase I | transcription, DNA-templated | response to epidermal growth factor | regulation of transcription, DNA-templated | organic acid metabolic process | cellular protein metabolic process | cellular macromolecule biosynthetic process | positive regulation of transcription, DNA-templated | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | aminoacyl-tRNA synthetase multienzyme complex | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytosol | intracellular | membrane