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QuickView for MASP2;jsessionid=BE0D63F12B7593106BAA6E012C1D62C1 (gene)


Gene Symbol:
MASP2 Homo sapiens Homo sapiens
Full name:
mannan binding lectin serine peptidase 2
Synonyms:
MAP19, MASP-2, MASP1P1, sMAP, mannan-binding lectin serine protease 2, MBL-associated plasma protein of 19 kD, MBL-associated serine protease 2, mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine protease 1 pseudogene 1, mannose-binding protein-associated serine protease 2, small MBL-associated protein
Genomic Location:
Chr 1: 11009167-11029872
Description:
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The enc...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1p36.22





GO Molecular Function

opsonin binding | cation binding | complement binding | hydrolase activity | complement component C4b binding | catalytic activity | serine hydrolase activity | calcium-dependent protein binding | ion binding | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | calcium ion binding | endopeptidase activity | metal ion binding | peptidase activity

GO Biological Process

positive regulation of immune response | adaptive immune response | proteolysis | complement activation | regulation of immune system process | defense response | regulation of immune response | response to stimulus | positive regulation of immune system process | response to stress | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | nitrogen compound metabolic process | leukocyte mediated immunity | protein activation cascade | humoral immune response | activation of immune response | protein metabolic process | complement activation, classical pathway | metabolic process | immune response | organic substance metabolic process | serine-type endopeptidase activity | serine-type peptidase activity | humoral immune response mediated by circulating immunoglobulin | complement activation, lectin pathway | endopeptidase activity | B cell mediated immunity | innate immune response | immunoglobulin mediated immune response | immune system process | peptidase activity | macromolecule metabolic process

GO Cellular Component

vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space