QuickView for MATa (biogroup)

Description:: This entry represents the MAT Alpha1 domain, which is diverged from the MATA HMG-box domain. All ascomycete MAT idiomorphs encode proteins with confirmed or putative DNA-binding motifs. The HMG-box domain can be found in a wide variety of DNA-binding proteins. In S. cerevisiae, there are two copies of Alpha1: one copy is localised at the MAT locus, the other is localised at the HML locus (MAT alpha 1). The HML locus (HML alpha 1) copy is usually silenced by the Sir2 histone deacetylase. MAT alpha 1 is a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression. It activates mating-type alpha-specific genes with the help of the MADS-box containing Mcm1 transcription factor, which together bind cooperatively to PQ elements upstream of alpha-specific genes. The MCM1-MATalpha1 complex is required for the proper DNA-bending that is needed for transcriptional activation. Alpha 1 interacts in vivo with Ste12, linking expression of alpha-specific genes to the alpha-pheromone response pathway.

1 feature

Symbol	EntrezGene ID
HMLALPHA1	850293