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QuickView for MC4R (gene)

Gene Symbol:
MC4R Homo sapiens Homo sapiens
Full name:
melanocortin 4 receptor
melanocortin receptor 4, MC4-R
Genomic Location:
Chr 18: 56189544-56190981
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 18

Transcripts Names
Protein Names

GO Molecular Function

peptide binding | peptide hormone binding | transmembrane signaling receptor activity | enzyme binding | neuropeptide binding | G-protein coupled receptor activity | ubiquitin-like protein ligase binding | amide binding | signaling receptor activity | hormone binding | protein binding | ubiquitin protein ligase binding | melanocyte-stimulating hormone receptor activity | peptide receptor activity | G-protein coupled peptide receptor activity | melanocortin receptor activity

GO Biological Process

response to extracellular stimulus | response to nutrient levels | intracellular signal transduction | hormone secretion | establishment of localization | response to hormone | generation of precursor metabolites and energy | adaptive thermogenesis | regulation of bone remodeling | cellular process | secretion | peptide hormone secretion | localization | protein transport | diet induced thermogenesis | macromolecule localization | response to peptide hormone | regulation of behavior | regulation of cellular process | regulation of metabolic process | G-protein coupled receptor activity | response to stimulus | regulation of feeding behavior | response to peptide | secretion by cell | G-protein coupled receptor signaling pathway | cell-cell signaling | insulin secretion | response to nitrogen compound | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of hormone levels | regulation of grooming behavior | organic substance transport | peptide transport | second-messenger-mediated signaling | peptide secretion | cell communication | cyclic-nucleotide-mediated signaling | response to organic substance | negative regulation of behavior | cAMP-mediated signaling | response to insulin | metabolic process | negative regulation of feeding behavior | oxidation-reduction process | regulation of bone resorption | regulation of tissue remodeling | amide transport | behavior | hormone transport | melanocyte-stimulating hormone receptor activity | establishment of protein localization | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | signaling | feeding behavior | G-protein coupled peptide receptor activity | energy reserve metabolic process | protein localization | positive regulation of tissue remodeling | energy derivation by oxidation of organic compounds | melanocortin receptor activity | positive regulation of bone resorption | response to dietary excess | signal release | response to organonitrogen compound | cellular metabolic process | protein secretion | signal transduction | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | intracellular organelle | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | intracellular | membrane