QuickView for MCM3 (gene)
- Gene Symbol:
- MCM3
Homo sapiens - Full name:
- minichromosome maintenance complex component 3
- Synonyms:
- HCC5, P1-MCM3, P1.h, RLFB, DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, MCM3 minichromosome maintenance deficient 3, RLF subunit beta, cervical cancer proto-oncogene 5, hRlf beta subunit, minichromosome maintenance deficient 3, p102, replication licensing factor, beta subunit
- Genomic Location:
- Chr 6: 52236771-52257541
- Description:
-
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Danio rerio , Schizosaccharomyces pombe , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
E2F1_Q4_01 , E2F4DP1_01 , E2F_Q6_01 , E2F_01 , E2F_Q6 , E2F1_Q6_01 , E2F_Q4 , E2F1DP2_01 , E2F_03 , E2F1DP1_01
- Cytogenetic Map:
-
6p12.2
GO Molecular Function
nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | helicase activity | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | DNA replication initiation | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | cellular biosynthetic process | nitrogen compound metabolic process | cell cycle | biosynthetic process | mitotic cell cycle phase transition | G1/S transition of mitotic cell cycle | DNA metabolic process | mitotic cell cycle | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | cellular macromolecule biosynthetic process | cell cycle phase transition | heterocycle metabolic process | cellular metabolic process | DNA replication | macromolecule metabolic process
GO Cellular Component
alpha DNA polymerase:primase complex | nuclear replisome | chromosome | intracellular membrane-bounded organelle | catalytic complex | nuclear replication fork | microtubule organizing center | cell | nuclear lumen | replication fork | nucleolus | cytoplasm | intracellular organelle | centrosome | protein-containing complex | protein-DNA complex | nucleoplasm | nuclear chromosome | transferase complex | perinuclear region of cytoplasm | microtubule cytoskeleton | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | replisome | RNA polymerase complex | membrane-enclosed lumen | cytoskeleton | nuclear chromosome, telomeric region | intracellular | MCM complex | membrane
