QuickView for MDH2 (gene)
- Gene Symbol:
- MDH2
Homo sapiens - Full name:
- malate dehydrogenase 2
- Synonyms:
- EIEE51, M-MDH, MDH, MGC:3559, MOR1, malate dehydrogenase, mitochondrial, malate dehydrogenase 2, NAD (mitochondrial), testicular tissue protein Li 120
- Genomic Location:
- Chr 7: 75515329-75533867
- Description:
-
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria....
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
7q11.23
GO Molecular Function
protein self-association | oxidoreductase activity, acting on CH-OH group of donors | nucleic acid binding | catalytic activity | malate dehydrogenase activity | L-malate dehydrogenase activity | organic cyclic compound binding | protein binding | malate dehydrogenase (NADP+) activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | RNA binding
GO Biological Process
oxidoreductase activity, acting on CH-OH group of donors | tricarboxylic acid cycle | glucose metabolic process | generation of precursor metabolites and energy | aerobic respiration | cellular process | dicarboxylic acid metabolic process | nucleotide metabolic process | cellular respiration | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | malate metabolic process | cellular nitrogen compound metabolic process | cofactor metabolic process | protein modification process | macromolecule modification | malate dehydrogenase activity | NADH metabolic process | nitrogen compound metabolic process | protein acetylation | antibiotic metabolic process | phosphorus metabolic process | organophosphate metabolic process | hexose biosynthetic process | monosaccharide metabolic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | carbohydrate biosynthetic process | biosynthetic process | L-malate dehydrogenase activity | carbohydrate metabolic process | phosphate-containing compound metabolic process | oxaloacetate metabolic process | drug metabolic process | carboxylic acid metabolic process | protein metabolic process | tricarboxylic acid metabolic process | metabolic process | malate dehydrogenase (NADP+) activity | hexose metabolic process | oxidation-reduction process | citrate metabolic process | gluconeogenesis | nucleobase-containing compound metabolic process | organic substance metabolic process | internal protein amino acid acetylation | organic acid metabolic process | cellular protein metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | energy derivation by oxidation of organic compounds | nicotinamide nucleotide metabolic process | cellular protein modification process | NAD metabolic process | heterocycle metabolic process | cellular metabolic process | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | intracellular | myelin sheath | membrane
