QuickView for MDM4 (gene)

Gene Symbol:

MDM4 Homo sapiens

Full name:

MDM4, p53 regulator

Synonyms:

HDMX, MDMX, MRP1, protein Mdm4, MDM4 protein variant G, MDM4 protein variant Y, MDM4-related protein 1, Mdm4 p53 binding protein homolog, double minute 4, human homolog of; p53-binding protein, mdm2-like p53-binding protein, protein Mdmx

Genomic Location:

Chr 1: 202752134-202786349

Description:

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However...

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This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MAZ_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CATRRAGC_UNKNOWN ,  SCGGAAGY_ELK1_02

Cytogenetic Map:

1q32.1

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