QuickView for ME2 (gene)

Gene Symbol:

ME2 Homo sapiens

Full name:

malic enzyme 2

Synonyms:

ODS1, NAD-dependent malic enzyme, mitochondrial, NAD-ME, malate dehydrogenase (oxaloacetate-decarboxylating), malic enzyme 2, NAD(+)-dependent, mitochondrial, pyruvic-malic carboxylase

Genomic Location:

Chr 18: 46659433-46728258

Description:

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide pol...

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This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

18q21.2

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