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QuickView for MED13 (gene)


Gene Symbol:
MED13 Homo sapiens Homo sapiens
Full name:
mediator complex subunit 13
Synonyms:
ARC250, DRIP250, HSPC221, THRAP1, TRAP240, mediator of RNA polymerase II transcription subunit 13, activator-recruited cofactor 250 kDa component, mediator of RNA polymerase II transcription, subunit 13 homolog, thyroid hormone receptor-associated protein 1, thyroid hormone receptor-associated protein complex 240 kDa component, thyroid hormone receptor-associated protein complex component TRAP240, thyroid hormone receptor-associated protein, 240 kDa subunit, vitamin D3 receptor-interacting protein complex component DRIP250
Genomic Location:
Chr 17: 57374748-57497425
Description:
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymera...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 CTTGTAT_MIR381 CACTGTG_MIR128A_MIR128B IRF1_01 GTATTAT_MIR3693P SMTTTTGT_UNKNOWN TGIF_01 MAZR_01 TAL1ALPHAE47_01 TTANTCA_UNKNOWN
Cytogenetic Map:
chr 17
17q23.2





GO Molecular Function

hormone receptor binding | signaling receptor binding | thyroid hormone receptor binding | signaling receptor activity | nuclear hormone receptor binding | transcription coactivator activity | protein binding | transcription factor binding | nuclear receptor transcription coactivator activity | transcription coregulator activity | vitamin D receptor binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | negative regulation of signaling receptor activity | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | response to hormone | negative regulation of cellular process | androgen receptor signaling pathway | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | positive regulation of nitrogen compound metabolic process | negative regulation of thyroid hormone receptor activity | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | sterol homeostasis | cholesterol homeostasis | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | steroid hormone mediated signaling pathway | cellular biosynthetic process | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | nitrogen compound metabolic process | regulation of signal transduction | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | triglyceride homeostasis | cell communication | regulation of cellular metabolic process | homeostatic process | transcription coactivator activity | regulation of RNA metabolic process | regulation of signaling receptor activity | response to organic substance | regulation of DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | nuclear receptor transcription coactivator activity | chemical homeostasis | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular macromolecule biosynthetic process | intracellular steroid hormone receptor signaling pathway | acylglycerol homeostasis | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | response to steroid hormone | lipid homeostasis | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | protein-containing complex | nucleoplasm | mediator complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | membrane