QuickView for MED1 (gene)

Gene Symbol:

MED1 Homo sapiens

Full name:

mediator complex subunit 1

Synonyms:

CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2, mediator of RNA polymerase II transcription subunit 1, ARC205, PPAR-binding protein, PPARG binding protein, TR-interacting protein 2, TRIP-2, activator-recruited cofactor 205 kDa component, p53 regulatory protein RB18A, peroxisome proliferator-activated receptor-binding protein, thyroid hormone receptor-associated protein complex 220 kDa component, thyroid hormone receptor-associated protein complex component TRAP220, thyroid receptor interacting protein 2, vitamin D receptor-interacting protein 230 kD, vitamin D receptor-interacting protein complex component DRIP205

Genomic Location:

Chr 17: 34814064-34861053

Description:

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation)...

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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  LYF1_01 ,  NFKAPPAB_01 ,  AGGAGTG_MIR483 ,  AAGCAAT_MIR137 ,  ATAGGAA_MIR202 ,  ACATTCC_MIR1_MIR206 ,  AAGWWRNYGGC_UNKNOWN ,  GATGKMRGCG_UNKNOWN ,  IK1_01 ,  ATGAAGG_MIR205 ,  GGARNTKYCCA_UNKNOWN ,  NFKB_Q6

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Cytogenetic Map:

17q12

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