QuickView for MEF2C;jsessionid=71A56389FA703FE693C9A4EEC1FAD010 (gene)

Gene Symbol:

MEF2C Homo sapiens

Full name:

myocyte enhancer factor 2C

Synonyms:

C5DELq14.3, DEL5q14.3, myocyte-specific enhancer factor 2C, MADS box transcription enhancer factor 2, polypeptide C

Genomic Location:

Chr 5: 88051922-88214780

Description:

This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this l...

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This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  PBX1_02 ,  PAX4_04 ,  GTGCCAT_MIR183 ,  HNF3ALPHA_Q6 ,  STAT4_01 ,  CTCTATG_MIR368 ,  TGANTCA_AP1_C ,  GATA1_03 ,  TAL1ALPHAE47_01 ,  AAGCCAT_MIR135A_MIR135B ,  GCATTTG_MIR105 ,  GNCF_01 ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  TGGNNNNNNKCCAR_UNKNOWN ,  FOX_Q2 ,  RSRFC4_01 ,  HFH3_01 ,  SREBP1_02 ,  HOXA4_Q2 ,  STAT6_02 ,  ATTACAT_MIR3803P ,  AAAYWAACM_HFH4_01 ,  AACTGAC_MIR223 ,  NGFIC_01 ,  FOXD3_01 ,  AAANWWTGC_UNKNOWN ,  CTTTGCA_MIR527 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  LXR_DR4_Q3 ,  TTTGTAG_MIR520D ,  IPF1_Q4 ,  LYF1_01 ,  ATGTACA_MIR493 ,  GATAAGR_GATA_C ,  TAGCTTT_MIR9 ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  RYCACNNRNNRNCAG_UNKNOWN ,  TGACCTY_ERR1_Q2 ,  CTTTGTA_MIR524 ,  WTGAAAT_UNKNOWN ,  MEF2_02 ,  AR_Q6 ,  GGTGTGT_MIR329 ,  RGAANNTTC_HSF1_01 ,  TAL1BETAE47_01 ,  CDP_02 ,  CATTTCA_MIR203 ,  TITF1_Q3 ,  CATGTAA_MIR496 ,  MEF2_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  NKX62_Q2 ,  HNF3_Q6 ,  NF1_Q6 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  AAGGGAT_MIR188 ,  YKACATTT_UNKNOWN ,  GATA6_01 ,  OCT1_03 ,  HIF1_Q5 ,  S8_01 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  HSF2_01 ,  RORA1_01 ,  GFI1_01 ,  AATGTGA_MIR23A_MIR23B ,  TTGCCAA_MIR182 ,  CETS1P54_01 ,  HAND1E47_01 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  CHOP_01 ,  CART1_01 ,  MEF2_03 ,  SMAD4_Q6 ,  TGCTTTG_MIR330 ,  TGATTTRY_GFI1_01 ,  AAGCACT_MIR520F ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  AAAGGAT_MIR501 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  FOXM1_01 ,  CCAATNNSNNNGCG_UNKNOWN ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  ERR1_Q2 ,  HIF1_Q3 ,  TGACCTTG_SF1_Q6 ,  CEBPGAMMA_Q6 ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-362 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

5q14.3

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