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QuickView for MEIS1;jsessionid=2BE570853BD2EBF9C5C28FD1B5FD7728 (gene)


Gene Symbol:
MEIS1 Homo sapiens Homo sapiens
Full name:
Meis homeobox 1
Synonyms:
homeobox protein Meis1, Meis1, myeloid ecotropic viral integration site 1 homolog, WUGSC:H_NH0444B04.1, leukemogenic homolog protein
Genomic Location:
Chr 2: 66516036-66653395
Description:
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 POU6F1_01 GATTGGY_NFY_Q6_01 RTAAACA_FREAC2_01 GTATTAT_MIR3693P PAX4_04 TFIIA_Q6 TTTGCAG_MIR518A2 OCT1_04 SYATTGTG_UNKNOWN
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-1 Predicted Gene Targets for miR-129 Predicted Gene Targets for miR-132 Predicted Gene Targets for miR-133 Predicted Gene Targets for miR-144 Predicted Gene Targets for miR-145 Predicted Gene Targets for miR-18 Predicted Gene Targets for miR-204 Predicted Gene Targets for miR-208 Predicted Gene Targets for miR-221
Cytogenetic Map:
chr 2
2p14


Transcripts Names
NM_002398
Protein Names
O00470
F5GYS8
A8MV50



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | regulation of neurogenesis | regulation of cell development | eye development | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | bone development | regulation of heart growth | cell differentiation | negative regulation of organ growth | nervous system development | neurogenesis | generation of neurons | blood vessel morphogenesis | regulation of cardiac muscle cell proliferation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | negative regulation of developmental growth | immune system development | regulation of striated muscle tissue development | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | myeloid cell development | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | negative regulation of cardiac muscle tissue development | vasculature development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | cardiovascular system development | cellular nitrogen compound metabolic process | negative regulation of muscle tissue development | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | hemopoiesis | negative regulation of hemopoiesis | cellular biosynthetic process | blood vessel development | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | negative regulation of growth | multicellular organism development | regulation of neuron differentiation | regulation of gene expression | positive regulation of cellular metabolic process | animal organ morphogenesis | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | definitive hemopoiesis | regulation of transcription by RNA polymerase II | biosynthetic process | locomotory behavior | aromatic compound biosynthetic process | angiogenesis | megakaryocyte differentiation | sensory organ development | negative regulation of cardiac muscle cell proliferation | regulation of cellular metabolic process | eye morphogenesis | negative regulation of striated muscle tissue development | regulation of RNA metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of growth | regulation of cardiac muscle tissue development | lens morphogenesis in camera-type eye | regulation of hemopoiesis | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | behavior | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | negative regulation of neuron differentiation | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | camera-type eye development | anatomical structure formation involved in morphogenesis | regulation of transcription, DNA-templated | cell development | regulation of developmental growth | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | camera-type eye morphogenesis | regulation of organ growth | regulation of nervous system development | regulation of developmental process | developmental process | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | megakaryocyte development | negative regulation of cell development | circulatory system development | negative regulation of cell differentiation | lens development in camera-type eye | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | transcription factor complex | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular