QuickView for MEK (gene)

Gene Symbol:

MAP2K7 Homo sapiens

Full name:

mitogen-activated protein kinase kinase 7

Synonyms:

JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, dual specificity mitogen-activated protein kinase kinase 7, JNK-activating kinase 2, MAP kinase kinase 7, MAPK/ERK kinase 7, SAPK kinase 4, c-Jun N-terminal kinase kinase 2, stress-activated protein kinase kinase 4

Genomic Location:

Chr 19: 7874765-7885363

Description:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involv...

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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  PAX4_04 ,  STAT4_01 ,  GGGCATT_MIR365 ,  CTCNANGTGNY_UNKNOWN ,  ACTGTGA_MIR27A_MIR27B ,  CAGGTA_AREB6_01 ,  CTCAGGG_MIR125B_MIR125A ,  CACCAGC_MIR138 ,  TGCGCANK_UNKNOWN ,  YGCANTGCR_UNKNOWN ,  ACCAAAG_MIR9 ,  SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  CAGCAGG_MIR370 ,  NRF1_Q6 ,  GFI1_01 ,  TAATTA_CHX10_01 ,  AFP1_Q6 ,  MSX1_01 ,  STAT5A_04 ,  GATA1_05 ,  CCAGGGG_MIR331 ,  CTGCAGY_UNKNOWN ,  TGATTTRY_GFI1_01 ,  ER_Q6_02 ,  RCGCANGCGY_NRF1_Q6 ,  ER_Q6_01 ,  LXR_Q3 ,  SP1_Q6_01 ,  YNGTTNNNATT_UNKNOWN ,  ER_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

19p13.2

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