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QuickView for MFGE8 (gene)


Gene Symbol:
MFGE8 Homo sapiens Homo sapiens
Full name:
milk fat globule-EGF factor 8 protein
Synonyms:
BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, lactadherin, O-acetyl disialoganglioside synthase, breast epithelial antigen BA46, medin, sperm associated antigen 10, sperm surface protein hP47
Genomic Location:
Chr 15: 87242920-87257614
Description:
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 15
15q26.1





GO Molecular Function

structural molecule activity | modified amino acid binding | protein-containing complex binding | lipid binding | signaling receptor binding | phospholipid binding | phosphatidylethanolamine binding | anion binding | ion binding | integrin binding | cell adhesion molecule binding | protein binding | phosphatidylserine binding | extracellular matrix structural constituent

GO Biological Process

positive regulation of cellular component organization | phagocytosis, engulfment | regulation of localization | establishment of localization | membrane organization | blood vessel morphogenesis | cellular process | localization | cell recognition | regulation of cellular process | cellular component organization | vasculature development | tube morphogenesis | reproduction | cardiovascular system development | apoptotic cell clearance | regulation of phagocytosis | protein modification process | macromolecule modification | blood vessel development | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | vesicle-mediated transport | angiogenesis | fertilization | positive regulation of transport | single fertilization | protein metabolic process | import into cell | phagocytosis, recognition | anatomical structure development | metabolic process | membrane invagination | regulation of vesicle-mediated transport | endocytosis | cell adhesion | organic substance metabolic process | positive regulation of phagocytosis | anatomical structure formation involved in morphogenesis | regulation of endocytosis | cellular protein metabolic process | anatomical structure morphogenesis | developmental process | cellular protein modification process | tube development | regulation of transport | cellular metabolic process | circulatory system development | sexual reproduction | phagocytosis | positive regulation of endocytosis | regulation of cellular component organization | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | extrinsic component of membrane | extracellular matrix | cell | extrinsic component of plasma membrane | external side of plasma membrane | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | endoplasmic reticulum | endomembrane system | plasma membrane | vesicle | endoplasmic reticulum lumen | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cell surface | intracellular | membrane