QuickView for MG44 (gene)

Gene Symbol:

SUV39H1 Homo sapiens

Full name:

suppressor of variegation 3-9 homolog 1

Synonyms:

H3-K9-HMTase 1, KMT1A, MG44, SUV39H, histone-lysine N-methyltransferase SUV39H1, Su(var)3-9 homolog 1, histone H3-K9 methyltransferase 1, histone-lysine N-methyltransferase, H3 lysine-9 specific 1, lysine N-methyltransferase 1A, position-effect variegation 3-9 homolog

Genomic Location:

Chr X: 48440075-48452351

Description:

This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromos...

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This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  GABP_B ,  MCAATNNNNNGCG_UNKNOWN ,  GATA1_01 ,  E2F1_Q4_01 ,  GATA_Q6 ,  E2F4DP1_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TMTCGCGANR_UNKNOWN ,  E2F_Q6_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  GGGAGGRR_MAZ_Q6 ,  CEBP_Q2 ,  GGGYGTGNY_UNKNOWN ,  E2F1_Q6_01 ,  CTCAGGG_MIR125B_MIR125A ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  NFY_Q6 ,  E2F_03 ,  GATA1_02 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  CEBP_Q3 ,  E2F_02 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  E2F4DP2_01 ,  AGGCACT_MIR5153P ,  E2F_Q3_01 ,  RRCCGTTA_UNKNOWN ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-93

Cytogenetic Map:

Xp11.23

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