QuickView for MIF (gene)
- Gene Symbol:
- MIF
Homo sapiens - Full name:
- macrophage migration inhibitory factor
- Synonyms:
- GIF, GLIF, MMIF, macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, macrophage migration inhibitory factor (glycosylation-inhibiting factor), phenylpyruvate tautomerase
- Genomic Location:
- Chr 22: 22566565-22567409
- Description:
-
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membran...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
22q11.23
GO Molecular Function
dopachrome isomerase activity | intramolecular oxidoreductase activity, transposing C=C bonds | phenylpyruvate tautomerase activity | isomerase activity | enzyme binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | catalytic activity | intramolecular oxidoreductase activity | identical protein binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | chemoattractant activity | protease binding
GO Biological Process
positive regulation of immune response | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | protein homooligomerization | regulation of cell cycle process | negative regulation of immune system process | exocytosis | response to cytokine | regulation of B cell activation | cell motility | neutrophil activation | intracellular signal transduction | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | regulation of cell aging | establishment of localization | regulation of immune system process | negative regulation of mature B cell apoptotic process | negative regulation of cellular process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | positive regulation of fibroblast proliferation | defense response | positive regulation of phosphate metabolic process | positive regulation of protein secretion | regulation of lipid transport | cellular process | unsaturated fatty acid biosynthetic process | secretion | leukocyte degranulation | regulation of cell motility | localization | positive regulation of protein kinase A signaling | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | positive regulation of immune effector process | positive regulation of peptidyl-serine phosphorylation | positive regulation of protein kinase activity | regulation of chemotaxis | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of macrophage migration | negative regulation of cell cycle arrest | negative regulation of cellular metabolic process | regulation of lymphocyte apoptotic process | negative regulation of apoptotic signaling pathway | negative regulation of cell motility | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | negative regulation of chemotaxis | positive regulation of cellular protein metabolic process | icosanoid biosynthetic process | cellular component organization | cellular lipid metabolic process | positive regulation of arachidonic acid secretion | positive regulation of tumor necrosis factor production | regulation of peptide secretion | response to stimulus | monocarboxylic acid metabolic process | neutrophil degranulation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of myeloid cell apoptotic process | response to stress | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of cell proliferation | regulation of chemokine (C-X-C motif) ligand 2 production | positive regulation of B cell proliferation | protein homotrimerization | positive regulation of cell activation | negative regulation of leukocyte chemotaxis | secretion by cell | positive regulation of cytokine secretion | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | cellular component assembly | regulation of peptide transport | cellular biosynthetic process | response to interleukin-12 | interleukin-12-mediated signaling pathway | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | molecular function regulator | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | positive chemotaxis | leukocyte migration | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | positive regulation of mononuclear cell proliferation | regulation of signal transduction | DNA damage response, signal transduction by p53 class mediator | positive regulation of icosanoid secretion | cell migration | regulation of MAPK cascade | cellular response to DNA damage stimulus | protein complex oligomerization | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | positive regulation of prostaglandin secretion involved in immune response | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | positive regulation of secretion | cellular response to stress | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | negative regulation of lymphocyte apoptotic process | regulation of nitrogen compound metabolic process | regulation of cell migration | negative regulation of signal transduction by p53 class mediator | small molecule metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | fatty acid biosynthetic process | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | negative regulation of B cell apoptotic process | regulation of cellular protein metabolic process | regulated exocytosis | lipid biosynthetic process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | positive regulation of chemokine production | positive regulation of lipid localization | regulation of apoptotic signaling pathway | regulation of tumor necrosis factor production | regulation of leukocyte migration | regulation of B cell apoptotic process | regulation of macrophage activation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | protein trimerization | inflammatory response | cell activation involved in immune response | regulation of cytokine production involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | positive regulation of B cell activation | positive regulation of transport | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | cell aging | carboxylic acid metabolic process | positive regulation of molecular function | regulation of cytokine secretion | positive regulation of myeloid leukocyte cytokine production involved in immune response | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | regulation of fibroblast proliferation | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | regulation of lipopolysaccharide-mediated signaling pathway | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | positive regulation of lipopolysaccharide-mediated signaling pathway | prostaglandin metabolic process | regulation of secretion | regulation of myeloid cell apoptotic process | receptor ligand activity | regulation of arachidonic acid secretion | regulation of response to DNA damage stimulus | immune response | cytokine activity | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | chemoattractant activity | negative regulation of gene expression | positive regulation of ion transport | negative regulation of cellular protein metabolic process | regulation of cell activation | negative regulation of cellular component movement | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | negative regulation of macrophage chemotaxis | regulation of phosphate metabolic process | fatty acid metabolic process | positive regulation of organic acid transport | positive regulation of cytokine production | negative regulation of cell aging | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of protein kinase A signaling | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | negative regulation of protein metabolic process | icosanoid metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of chemokine (C-X-C motif) ligand 2 production | organic acid metabolic process | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of MAP kinase activity | negative regulation of leukocyte migration | regulation of developmental process | regulation of ion transport | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | positive regulation of anion transport | positive regulation of prostaglandin secretion | regulation of chemokine production | regulation of transport | regulation of B cell proliferation | innate immune response | regulation of fatty acid transport | neutrophil mediated immunity | prostaglandin biosynthetic process | regulation of anion transport | regulation of macrophage chemotaxis | positive regulation of metabolic process | positive regulation of lipid transport | immune system process | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of protein localization | regulation of cell death | signal transduction by p53 class mediator | negative regulation of cell death | aging | chemotaxis | negative regulation of locomotion | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of fatty acid transport | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | nuclear lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | secretory vesicle | endomembrane system | nucleoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | secretory granule lumen | cytosol | intracellular vesicle | cell surface | intracellular | myelin sheath | vesicle lumen
