QuickView for MITF (gene)

Gene Symbol:

MITF Homo sapiens

Full name:

melanogenesis associated transcription factor

Synonyms:

CMM8, COMMAD, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, class E basic helix-loop-helix protein 32, microphtalmia-associated transcription factor

Genomic Location:

Chr 3: 69871323-70100177

Description:

The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigment...

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The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  YTCCCRNNAGGY_UNKNOWN ,  FOXO1_02 ,  CTTGTAT_MIR381 ,  IRF1_01 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  STAT4_01 ,  TGANTCA_AP1_C ,  CEBPA_01 ,  OCT1_B ,  HNF1_01 ,  TTANTCA_UNKNOWN ,  CREBP1CJUN_01 ,  OCT1_04 ,  FOX_Q2 ,  EFC_Q6 ,  NFAT_Q6 ,  OCT1_01 ,  HOXA4_Q2 ,  GATA3_01 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  AAAYWAACM_HFH4_01 ,  LXR_DR4_Q3 ,  RSRFC4_Q2 ,  CEBP_Q2_01 ,  YATTNATC_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  TACTTGA_MIR26A_MIR26B ,  TAAYNRNNTCC_UNKNOWN ,  GATAAGR_GATA_C ,  TAGCTTT_MIR9 ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  AAGCAAT_MIR137 ,  PBX1_01 ,  MAF_Q6 ,  GATA1_04 ,  TGACCTY_ERR1_Q2 ,  CREB_Q3 ,  NFKAPPAB65_01 ,  TCF4_Q5 ,  COMP1_01 ,  CTTTGTA_MIR524 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  CDP_01 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  CEBPDELTA_Q6 ,  NFE2_01 ,  CEBPB_01 ,  DBP_Q6 ,  PAX4_02 ,  GGGYGTGNY_UNKNOWN ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  P53_02 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  PXR_Q2 ,  GR_Q6 ,  NKX62_Q2 ,  TGCCTTA_MIR124A ,  ATTCTTT_MIR186 ,  HNF3B_01 ,  ATF3_Q6 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  PITX2_Q2 ,  ACTGCCT_MIR34B ,  LMO2COM_02 ,  GTGCCAA_MIR96 ,  AP1_Q2_01 ,  OCT1_03 ,  ACTAYRNNNCCCR_UNKNOWN ,  S8_01 ,  MGGAAGTG_GABP_B ,  FOXO1_01 ,  CTTTAAR_UNKNOWN ,  GCM_Q2 ,  TGCCAAR_NF1_Q6 ,  HFH4_01 ,  GCCNNNWTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  GATA1_02 ,  YCATTAA_UNKNOWN ,  GTGCCTT_MIR506 ,  EN1_01 ,  TTGCCAA_MIR182 ,  FREAC2_01 ,  CHX10_01 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  SNACANNNYSYAGA_UNKNOWN ,  MSX1_01 ,  RTTTNNNYTGGM_UNKNOWN ,  STAT5A_04 ,  TATA_01 ,  TGACGTCA_ATF3_Q6 ,  RGTTAMWNATT_HNF1_01 ,  GTGGGTGK_UNKNOWN ,  CREL_01 ,  CCCNNNNNNAAGWT_UNKNOWN ,  TACAATC_MIR508 ,  SRF_Q5_01 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  PAX3_B ,  ER_Q6_01 ,  NFKB_Q6_01 ,  CAGCTG_AP4_Q5 ,  LXR_Q3 ,  MMEF2_Q6 ,  FOXM1_01 ,  SRY_02 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  DR4_Q2 ,  GGARNTKYCCA_UNKNOWN ,  ELF1_Q6 ,  CEBPGAMMA_Q6 ,  CREB_01 ,  HNF6_Q6 ,  SRF_C ,  IRF2_01 ,  AAGCACA_MIR218 ,  TCF11MAFG_01 ,  STAT5A_02 ,  TCF11_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-378

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miRNA binding sites
(Source: miRecords):

hsa-miR-182 Targeted Genes ,  hsa-miR-96 Targeted Genes

Cytogenetic Map:

3p13

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