QuickView for MKL1 (gene)
- Gene Symbol:
- MKL1
Homo sapiens - Full name:
- megakaryoblastic leukemia (translocation) 1
- Synonyms:
- BSAC, MAL, MKL, MRTF-A, MKL/myocardin-like protein 1, basic, SAP and coiled-coil domain, megakaryoblastic leukemia 1 protein, megakaryocytic acute leukemia protein, myocardin-related transcription factor A
- Genomic Location:
- Chr 22: 39136238-39362636
- Description:
-
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and th...
- Orthologs:
- Mus musculus , Rattus norvegicus , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
22q13.1-q13.2
GO Molecular Function
actin binding | protein domain specific binding | cytoskeletal protein binding | transcription coactivator activity | protein binding | leucine zipper domain binding | LRR domain binding | actin monomer binding | transcription coregulator activity
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | smooth muscle cell differentiation | cell differentiation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of nitrogen compound metabolic process | muscle structure development | muscle cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | transcription coactivator activity | regulation of RNA metabolic process | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription via serum response element binding | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
