QuickView for MKP-1 (gene)

Gene Symbol:

DUSP1 Homo sapiens

Full name:

dual specificity phosphatase 1

Synonyms:

CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity protein phosphatase 1, CL 100, MAP kinase phosphatase 1, dual specificity protein phosphatase hVH1, mitogen-activated protein kinase phosphatase 1, protein-tyrosine phosphatase CL100, serine/threonine specific protein phosphatase

Genomic Location:

Chr 5: 172127707-172130809

Description:

The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the neg...

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The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  RTAAACA_FREAC2_01 ,  USF_Q6 ,  TTANTCA_UNKNOWN ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  HFH3_01 ,  AML_Q6 ,  CACGTG_MYC_Q2 ,  AAAYWAACM_HFH4_01 ,  AAANWWTGC_UNKNOWN ,  HFH1_01 ,  MAX_01 ,  GGGACCA_MIR133A_MIR133B ,  ATF4_Q2 ,  GTACTGT_MIR101 ,  CREB_Q4 ,  CREB_Q3 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  RGAANNTTC_HSF1_01 ,  CEBPB_01 ,  GTGACGY_E4F1_Q6 ,  ATF_01 ,  ATACCTC_MIR202 ,  HSF1_01 ,  CREB_02 ,  HNF3B_01 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  CEBPB_02 ,  E4F1_Q6 ,  FOXO1_01 ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  USF_01 ,  HSF2_01 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  USF_02 ,  CREB_Q2_01 ,  CREB_01 ,  FREAC4_01 ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

5q35.1

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