QuickView for MMP-9 (gene)

Gene Symbol:

MMP9 Homo sapiens

Full name:

matrix metallopeptidase 9

Synonyms:

CLG4B, GELB, MANDP2, MMP-9, matrix metalloproteinase-9, macrophage gelatinase, matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), type V collagenase

Genomic Location:

Chr 20: 44070954-44078607

Description:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when...

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  TGANNYRGCA_TCF11MAFG_01 ,  AML_Q6 ,  NFKAPPAB_01 ,  AP1_Q6 ,  NFKAPPAB65_01 ,  BACH2_01 ,  GCM_Q2 ,  GCCNNNWTAAR_UNKNOWN ,  AP1_Q4 ,  RGAGGAARY_PU1_Q6 ,  CTGCAGY_UNKNOWN ,  CREL_01 ,  AP1_Q2 ,  NFKB_Q6_01 ,  AP1_Q4_01 ,  TGASTMAGC_NFE2_01

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Cytogenetic Map:

20q13.12

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