QuickView for MMP3 (gene)

Gene Symbol:

MMP3 Homo sapiens

Full name:

matrix metallopeptidase 3

Synonyms:

CHDS6, MMP-3, SL-1, STMY, STMY1, STR1, stromelysin-1, matrix metalloproteinase 3 (stromelysin 1, progelatinase), proteoglycanase, transin-1

Genomic Location:

Chr 11: 102211738-102219552

Description:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when...

View Full Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGANTCA_AP1_C ,  ETS_Q4 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  AAANWWTGC_UNKNOWN ,  STAT_Q6 ,  TATAAA_TATA_01 ,  ETS2_B ,  TATA_C ,  BACH1_01 ,  ETS1_B

View More

View Less

Cytogenetic Map:

11q22.2

search → result