QuickView for MPP5 (gene)

Gene Symbol:

MPP5 Homo sapiens

Full name:

membrane palmitoylated protein 5

Synonyms:

PALS1, MAGUK p55 subfamily member 5, membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5), protein associated with Lin-7 1, protein associated with lin seven 1, stardust

Genomic Location:

Chr 14: 66777774-66872289

Description:

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which ...

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This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CRGAARNNNNCGA_UNKNOWN ,  SP1_01 ,  HNF4ALPHA_Q6 ,  AP1_C ,  TGANTCA_AP1_C ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HOXA4_Q2 ,  TTTTGAG_MIR373 ,  GATA_C ,  E4BP4_01 ,  CEBP_Q2_01 ,  IPF1_Q4 ,  AACTGGA_MIR145 ,  TAGCTTT_MIR9 ,  CTTTGA_LEF1_Q2 ,  COUP_01 ,  TTAYRTAA_E4BP4_01 ,  GGGCGGR_SP1_Q6 ,  CREBP1_01 ,  OCT1_03 ,  AHR_Q5 ,  NRF1_Q6 ,  YCATTAA_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  CTTTGT_LEF1_Q2 ,  RCGCANGCGY_NRF1_Q6 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  PAX2_02 ,  HNF4_01_B ,  ACACTGG_MIR199A_MIR199B ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-375

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Cytogenetic Map:

14q23.3

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