QuickView for MPTP (gene)
- Gene Symbol:
- Ptpn2
Mus musculus - Full name:
- protein tyrosine phosphatase, non-receptor type 2
- Synonyms:
- AI325124, Ptpt, TC-PTP, tyrosine-protein phosphatase non-receptor type 2, MPTP, T cell protein-tyrosine phosphatase, protein-tyrosine phosphatase PTP-2
- Genomic Location:
- Chr 18: 67825167-67884231
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
kinase binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | protein-containing complex binding | syntaxin binding | phosphatase activity | signaling receptor binding | hydrolase activity | STAT family protein binding | protein tyrosine phosphatase activity | catalytic activity | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | integrin binding | protein tyrosine kinase binding | cell adhesion molecule binding | protein binding | phosphoric ester hydrolase activity | SNARE binding | non-membrane spanning protein tyrosine phosphatase activity
GO Biological Process
negative regulation of lymphocyte differentiation | positive regulation of endoplasmic reticulum unfolded protein response | negative regulation of leukocyte activation | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | negative regulation of cellular response to insulin stimulus | negative regulation of MAPK cascade | negative regulation of immune system process | protein dephosphorylation | regulation of endoplasmic reticulum unfolded protein response | positive regulation of apoptotic process | regulation of localization | regulation of carbohydrate metabolic process | regulation of programmed cell death | erythrocyte homeostasis | negative regulation of interleukin-2-mediated signaling pathway | regulation of immune system process | response to hormone | myeloid cell differentiation | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of leukocyte cell-cell adhesion | negative regulation of RNA biosynthetic process | cell differentiation | regulation of T cell differentiation | positive regulation of intrinsic apoptotic signaling pathway | negative regulation of protein phosphorylation | glucose homeostasis | B cell differentiation | regulation of response to interferon-gamma | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | lymphocyte differentiation | negative regulation of signaling | negative regulation of T cell receptor signaling pathway | immune system development | negative regulation of tumor necrosis factor-mediated signaling pathway | negative regulation of nucleic acid-templated transcription | negative regulation of innate immune response | regulation of response to cytokine stimulus | regulation of chemotaxis | regulation of tyrosine phosphorylation of STAT protein | regulation of myeloid cell differentiation | negative regulation of cellular metabolic process | response to peptide hormone | regulation of T cell receptor signaling pathway | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | negative regulation of chemotaxis | regulation of interferon-gamma-mediated signaling pathway | cellular response to organonitrogen compound | negative regulation of epidermal growth factor receptor signaling pathway | negative regulation of platelet-derived growth factor receptor-beta signaling pathway | T cell activation | phosphatase activity | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | negative regulation of cell adhesion | negative regulation of JAK-STAT cascade | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | regulation of response to endoplasmic reticulum stress | regulation of cell proliferation | response to peptide | negative regulation of tyrosine phosphorylation of STAT protein | negative regulation of metabolic process | hemopoiesis | negative regulation of hemopoiesis | protein modification process | regulation of cell adhesion | regulation of PERK-mediated unfolded protein response | macromolecule modification | regulation of lipid storage | negative regulation of ERK1 and ERK2 cascade | protein tyrosine phosphatase activity | regulation of lymphocyte differentiation | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | leukocyte differentiation | negative regulation of interleukin-6-mediated signaling pathway | regulation of cellular response to stress | response to nitrogen compound | cellular response to hormone stimulus | regulation of protein tyrosine kinase activity | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of MAPK cascade | phosphorus metabolic process | cellular response to insulin stimulus | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | positive regulation of gluconeogenesis | regulation of T cell activation | regulation of gene expression | cellular response to peptide | negative regulation of type I interferon-mediated signaling pathway | insulin receptor signaling pathway | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of hepatocyte growth factor receptor signaling pathway | negative regulation of lipid storage | negative regulation of myeloid cell differentiation | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | phosphoprotein phosphatase activity | regulation of platelet-derived growth factor receptor signaling pathway | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | negative regulation of insulin receptor signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | positive regulation of PERK-mediated unfolded protein response | negative regulation of positive thymic T cell selection | homeostasis of number of cells | B cell activation | regulation of cellular protein metabolic process | negative regulation of immune response | regulation of apoptotic signaling pathway | phosphate-containing compound metabolic process | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of macrophage differentiation | negative regulation of cell activation | regulation of tumor necrosis factor-mediated signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | regulation of RNA metabolic process | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | negative regulation of T cell differentiation | lymphocyte activation | negative regulation of interferon-gamma-mediated signaling pathway | T cell differentiation | protein metabolic process | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | regulation of JAK-STAT cascade | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | response to insulin | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | regulation of glucose metabolic process | metabolic process | positive regulation of glucose metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | chemical homeostasis | positive regulation of cell death | negative regulation of ERBB signaling pathway | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | negative regulation of biosynthetic process | regulation of type I interferon-mediated signaling pathway | negative regulation of gene expression | animal organ development | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of programmed cell death | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | negative regulation of macrophage colony-stimulating factor signaling pathway | cell activation | negative regulation of protein metabolic process | positive regulation of carbohydrate metabolic process | regulation of cell communication | dephosphorylation | regulation of macrophage differentiation | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of ERBB signaling pathway | negative regulation of peptidyl-tyrosine phosphorylation | regulation of T cell differentiation in thymus | cellular protein metabolic process | regulation of developmental process | developmental process | erythrocyte differentiation | cellular protein modification process | negative regulation of transcription by RNA polymerase II | non-membrane spanning protein tyrosine phosphatase activity | negative regulation of cell proliferation | peptidyl-tyrosine dephosphorylation | regulation of cell-cell adhesion | response to organonitrogen compound | negative regulation of cytokine-mediated signaling pathway | regulation of gluconeogenesis | regulation of positive thymic T cell selection | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | negative regulation of interleukin-4-mediated signaling pathway | immune system process | cellular metabolic process | negative regulation of platelet-derived growth factor receptor signaling pathway | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | negative regulation of protein tyrosine kinase activity | regulation of inflammatory response | carbohydrate homeostasis | negative regulation of T cell differentiation in thymus | negative regulation of locomotion | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
endoplasmic reticulum-Golgi intermediate compartment | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | nucleoplasm | plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane
