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QuickView for MRAP2 (gene)


Gene Symbol:
MRAP2 Homo sapiens Homo sapiens
Full name:
melanocortin 2 receptor accessory protein 2
Synonyms:
C6orf117, bA51G5.2, melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2
Genomic Location:
Chr 6: 84800139-84857325
Description:
This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be assoc...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6q14.2





GO Molecular Function

type 5 melanocortin receptor binding | corticotropin hormone receptor binding | signaling receptor binding | neuropeptide receptor binding | molecular function regulator | type 3 melanocortin receptor binding | identical protein binding | protein binding | receptor regulator activity | G-protein coupled receptor binding | type 4 melanocortin receptor binding | type 1 melanocortin receptor binding | melanocortin receptor binding

GO Biological Process

negative regulation of G-protein coupled receptor protein signaling pathway | protein localization to cell periphery | regulation of cellular localization | regulation of localization | negative regulation of cellular process | regulation of protein localization to membrane | generation of precursor metabolites and energy | cellular process | localization | negative regulation of signaling | negative regulation of protein localization to plasma membrane | macromolecule localization | regulation of cellular process | regulation of cellular protein localization | positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | multicellular organismal homeostasis | cellular localization | molecular function regulator | regulation of signal transduction | negative regulation of cellular protein localization | protein localization to plasma membrane | protein localization to membrane | positive regulation of intracellular signal transduction | energy homeostasis | positive regulation of signal transduction | regulation of cAMP-mediated signaling | homeostatic process | regulation of signaling receptor activity | receptor regulator activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | metabolic process | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of protein localization to plasma membrane | oxidation-reduction process | cellular protein localization | behavior | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of cAMP-mediated signaling | regulation of cell communication | negative regulation of signal transduction | feeding behavior | energy reserve metabolic process | protein localization | cellular macromolecule localization | regulation of G-protein coupled receptor protein signaling pathway | energy derivation by oxidation of organic compounds | negative regulation of cAMP-mediated signaling | cellular metabolic process | regulation of protein localization | positive regulation of signaling | regulation of signaling | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | plasma membrane | membrane-bounded organelle | organelle | cell periphery | intracellular | membrane