QuickView for MRM3 (gene)

Gene Symbol:

MRM3 Homo sapiens

Full name:

mitochondrial rRNA methyltransferase 3

Synonyms:

RMTL1, RNMTL1, rRNA methyltransferase 3, mitochondrial, 16S rRNA (guanosine(1370)-2'-O)-methyltransferase, 16S rRNA [Gm1370] 2'-O-methyltransferase, RNA methyltransferase like 1, RNA methyltransferase-like protein 1, putative RNA methyltransferase

Genomic Location:

Chr 17: 632263-642491

Description:

Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates ...

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Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CREBP1CJUN_01 ,  TGAYRTCA_ATF3_Q6 ,  GTGACGY_E4F1_Q6 ,  CREB_02 ,  E4F1_Q6 ,  TGACGTCA_ATF3_Q6 ,  CREB_01

Cytogenetic Map:

17p13.3

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