QuickView for MT3 (gene)

Gene Symbol:

MT3 Homo sapiens

Full name:

metallothionein 3

Synonyms:

GIF, GIFB, GRIF, ZnMT3, metallothionein-3, growth inhibitory factor, metallothionein 3 (growth inhibitory factor (neurotrophic)), metallothionein-III

Genomic Location:

Chr 16: 55180768-55182501

Description:

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapepti...

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This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  MYOD_Q6_01 ,  TGANTCA_AP1_C ,  MYOD_01 ,  YGTCCTTGR_UNKNOWN ,  TATAAA_TATA_01 ,  CAGGTG_E12_Q6 ,  TATA_C ,  TATA_01 ,  ZF5_B ,  TGASTMAGC_NFE2_01

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Cytogenetic Map:

16q13

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