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QuickView for MTA2 (gene)


Gene Symbol:
MTA2 Homo sapiens Homo sapiens
Full name:
metastasis associated 1 family member 2
Synonyms:
MTA1L1, PID, metastasis-associated protein MTA2, MTA1-L1 protein, metastasis -associated gene 1-like 1, metastasis associated gene family, member 2, metastasis-associated 1-like 1, metastasis-associated protein 2, p53 target protein in deacetylase complex
Genomic Location:
Chr 11: 62117251-62125879
Description:
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 11
11q12.3


Transcripts Names
NM_004739
NM_001330292
Protein Names
A0A024R534
Q9UQB5
O94776



GO Molecular Function

sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | repressing transcription factor binding | nucleosome binding | enzyme binding | nucleic acid binding | protein-containing complex binding | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | histone deacetylase activity | RNA polymerase II repressing transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | nucleosomal DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | chromatin DNA binding | RNA polymerase II transcription factor binding | transition metal ion binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | histone deacetylase binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | regulation of localization | DNA modification | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | histone modification | histone deacetylation | regulation of fibroblast migration | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | chromatin organization | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | ATP-dependent chromatin remodeling | regulation of gene expression | histone deacetylase activity | methylation | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cell migration | transcription corepressor activity | regulation of cellular component movement | regulation of transcription by RNA polymerase II | DNA methylation | protein deacetylation | regulation of cellular metabolic process | chromatin remodeling | regulation of locomotion | transcription coactivator activity | regulation of RNA metabolic process | protein metabolic process | DNA-binding transcription factor activity | DNA metabolic process | chromatin assembly or disassembly | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | nuclear transcriptional repressor complex | transcription factor complex | intracellular organelle | protein-containing complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | SWI/SNF superfamily-type complex | NuRD complex | membrane-enclosed lumen | nuclear chromatin | ATPase complex | intracellular | membrane