QuickView for MTOR (gene)
- Gene Symbol:
- MTOR
Homo sapiens - Full name:
- mechanistic target of rapamycin kinase
- Synonyms:
- FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, serine/threonine-protein kinase mTOR, FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, FKBP12-rapamycin complex-associated protein 1, mammalian target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, rapamycin target protein 1
- Genomic Location:
- Chr 1: 11089179-11245153
- Description:
-
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Saccharomyces cerevisiae , Bos taurus , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1p36.22
| Transcripts Names |
|---|
| NM_004958 |
| XM_017000901 |
| XM_024446187 |
| XM_017000902 |
| XM_017000900 |
| XR_001737087 |
| XM_011541166 |
| XM_005263438 |
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ribonucleoprotein complex binding | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | ribosome binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein binding | double-stranded DNA binding | transcription factor binding | transferase activity, transferring phosphorus-containing groups | rDNA binding | phosphotransferase activity, alcohol group as acceptor | RNA polymerase III type 1 promoter DNA binding | protein kinase activity | TFIIIC-class transcription factor binding | transferase activity | RNA polymerase III type 2 promoter DNA binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | RNA polymerase III regulatory region DNA binding | heterocyclic compound binding | RNA polymerase III type 3 promoter DNA binding | small molecule binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | negative regulation of phosphorylation | brain development | positive regulation of striated muscle cell differentiation | regulation of supramolecular fiber organization | multicellular organismal movement | adaptive immune response | response to radiation | regulation of muscle system process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | heart process | positive regulation of granulosa cell proliferation | response to nutrient levels | TORC1 signaling | positive regulation of behavior | CD4-positive, alpha-beta T cell differentiation | long-term memory | positive regulation of cellular component organization | positive regulation of wound healing, spreading of epidermal cells | regulation of neurogenesis | CD4-positive, alpha-beta T cell activation | ruffle organization | RNA stabilization | developmental process involved in reproduction | muscle tissue development | intracellular signal transduction | regulation of cell development | regulation of localization | response to isoquinoline alkaloid | positive regulation of striated muscle tissue development | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of cardiac muscle cell differentiation | positive regulation of peptidyl-tyrosine phosphorylation | T cell lineage commitment | peptidyl-amino acid modification | regulation of transcription by RNA polymerase I | regulation of autophagy | regulation of immune system process | response to hormone | positive regulation of phosphoprotein phosphatase activity | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | positive regulation of skeletal muscle hypertrophy | mRNA stabilization | positive regulation of developmental process | social behavior | regulation of phosphatase activity | T-helper cell lineage commitment | regulation of heart growth | cell differentiation | positive regulation of epithelial cell proliferation | striated muscle cell development | nervous system development | cellular response to extracellular stimulus | response to drug | multicellular organism growth | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | regulation of actin polymerization or depolymerization | generation of neurons | cardiac cell development | positive regulation of sensory perception of pain | regulation of neuron death | positive regulation of dephosphorylation | positive regulation of eating behavior | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of actin filament polymerization | organic substance catabolic process | response to morphine | lymphocyte differentiation | musculoskeletal movement | positive regulation of keratinocyte migration | regulation of cell motility | negative regulation of calcineurin-mediated signaling | negative regulation of iodide transmembrane transport | positive regulation of neuron maturation | regulation of calcium-mediated signaling | heart morphogenesis | negative regulation of macroautophagy | negative regulation of signaling | developmental growth | regulation of cell growth involved in cardiac muscle cell development | visual learning | positive regulation of reactive oxygen species metabolic process | positive regulation of epithelial to mesenchymal transition | TOR signaling | T-helper 1 type immune response | female pregnancy | immune system development | multicellular organismal reproductive process | learning | response to leucine | regulation of skeletal muscle adaptation | regulation of striated muscle tissue development | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | cellular response to starvation | regulation of cell cycle | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | regulation of neuron projection development | negative regulation of cellular metabolic process | response to peptide hormone | regulation of behavior | tissue development | regulation of transcription by RNA polymerase III | regulation of fat cell differentiation | regulation of myeloid leukocyte differentiation | regulation of neurological system process | regulation of cell differentiation | gamete generation | positive regulation of cardiac muscle hypertrophy | positive regulation of muscle cell differentiation | muscle structure development | muscle cell differentiation | regulation of myotube differentiation | regulation of mRNA stability | positive regulation of lamellipodium assembly | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of lamellipodium organization | leukocyte activation | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | T cell differentiation involved in immune response | negative regulation of muscle atrophy | heart contraction | organic cyclic compound metabolic process | positive regulation of translation | regulation of cell maturation | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | negative regulation of calcium-mediated signaling | positive regulation of epithelial cell migration | T cell activation | regulation of actin filament length | head development | regulation of translational initiation | muscle contraction | associative learning | response to stimulus | negative regulation of epithelial cell apoptotic process | peptidyl-threonine phosphorylation | regulation of carbohydrate utilization | muscle cell development | regulation of feeding behavior | alpha-beta T cell activation involved in immune response | regulation of cellular response to heat | regulation of peptidyl-tyrosine phosphorylation | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | response to cocaine | cellular response to hypoxia | response to stress | leukocyte activation involved in immune response | germ cell development | positive regulation of feeding behavior | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | positive regulation of lipid biosynthetic process | regulation of protein ubiquitination | positive regulation of actin filament bundle assembly | response to peptide | cardiac muscle tissue development | response to starvation | protein serine/threonine kinase activity | programmed cell death | positive regulation of phosphatase activity | positive regulation of transcription by RNA polymerase III | reproduction | cellular nitrogen compound metabolic process | regulation of macroautophagy | negative regulation of transport | positive regulation of gliogenesis | blood circulation | negative regulation of metabolic process | regulation of cellular component size | positive regulation of RNA biosynthetic process | hemopoiesis | regulation of wound healing | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of oligodendrocyte differentiation | negative regulation of transmembrane transport | positive regulation of protein dephosphorylation | activation of protein kinase activity | voluntary musculoskeletal movement | positive regulation of stress fiber assembly | regulation of nucleic acid-templated transcription | T-helper cell differentiation | leukocyte differentiation | regulation of cellular response to stress | regulation of neurotransmitter levels | response to nitrogen compound | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | response to light stimulus | regulation of cell projection assembly | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | cellular response to nutrient levels | response to oxygen levels | positive regulation of response to wounding | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | regulation of fatty acid beta-oxidation | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | regulation of actin cytoskeleton organization | multicellular organism development | response to activity | phosphorus metabolic process | regulation of neuron maturation | response to amino acid | regulation of actin filament organization | learning or memory | positive regulation of muscle organ development | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of actomyosin structure organization | regulation of phosphorylation | regulation of sensory perception of pain | T-helper 1 cell differentiation | wound healing | cellular response to amino acid starvation | anoikis | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | nervous system process | regulation of response to food | cell cycle | protein catabolic process | alpha-beta T cell lineage commitment | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | response to ammonium ion | cellular response to oxygen levels | regulation of myelination | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | regulation of RNA stability | cardiocyte differentiation | positive regulation of protein complex assembly | negative regulation of calcineurin-NFAT signaling cascade | regulation of cellular component movement | alpha-beta T cell differentiation | response to nutrient | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cell differentiation | nucleobase-containing small molecule metabolic process | activation of protein kinase B activity | cognition | positive regulation of cell migration | negative regulation of ion transmembrane transport | biosynthetic process | regulation of cellular protein metabolic process | cardiac muscle cell development | positive regulation of cell maturation | cellular response to leucine | phosphorylation | T cell activation involved in immune response | negative regulation of ion transport | positive regulation of neuron death | regulation of GTPase activity | positive regulation of cell growth involved in cardiac muscle cell development | positive regulation of dendritic spine development | response to xenobiotic stimulus | cellular response to amino acid stimulus | pyrimidine nucleobase biosynthetic process | regulation of epithelial cell apoptotic process | protein phosphorylation | post-embryonic development | phosphate-containing compound metabolic process | negative regulation of autophagy | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I | regulation of actin filament polymerization | regulation of lipid catabolic process | regulation of glial cell proliferation | cell activation involved in immune response | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | negative regulation of protein ubiquitination | striated muscle contraction | regulation of lipid biosynthetic process | striated muscle cell differentiation | negative regulation of cholangiocyte apoptotic process | cell aging | positive regulation of dendrite development | lymphocyte activation | negative regulation of mRNA catabolic process | positive regulation of glial cell proliferation | positive regulation of cytoplasmic translational initiation | positive regulation of molecular function | positive regulation of translational initiation | multicellular organism reproduction | T cell differentiation | maternal process involved in female pregnancy | positive regulation of organ growth | heart valve development | protein metabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | regulation of growth | T cell selection | response to organic substance | regulation of cardiac muscle tissue development | regulation of eating behavior | visual behavior | regulation of hemopoiesis | cell cycle arrest | regulation of protein dephosphorylation | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | response to insulin | anatomical structure development | positive regulation of neurogenesis | regulation of glucose metabolic process | 'de novo' pyrimidine nucleobase biosynthetic process | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | positive regulation of supramolecular fiber organization | regulation of RNA biosynthetic process | oxidation-reduction process | negative regulation of programmed cell death | negative regulation of cell size | positive T cell selection | positive regulation of glial cell differentiation | behavior | positive regulation of cell death | immune response | nucleobase-containing compound metabolic process | protein kinase activity | positive regulation of cellular component biogenesis | heart valve morphogenesis | organic substance metabolic process | cell death | animal organ development | regulation of mRNA catabolic process | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | positive regulation of transcription by RNA polymerase I | positive regulation of kinase activity | alpha-beta T cell activation | regulation of calcineurin-NFAT signaling cascade | regulation of fatty acid oxidation | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | positive regulation of wound healing | response to alkaloid | regulation of ion transmembrane transport | T-helper 1 cell lineage commitment | positive regulation of cytoplasmic translation | positive regulation of muscle tissue development | regulation of brown fat cell differentiation | regulation of cytoplasmic translation | cell activation | regulation of reactive oxygen species biosynthetic process | regulation of stress fiber assembly | negative regulation of cell cycle | memory | negative regulation of protein metabolic process | regulation of dendrite development | regulation of epithelial cell migration | positive regulation of cardiac muscle cell differentiation | organonitrogen compound catabolic process | regulation of osteoclast differentiation | cardiac muscle cell differentiation | regulation of glial cell differentiation | regulation of response to wounding | regulation of cell communication | regulation of membrane permeability | regulation of gliogenesis | pyrimidine nucleobase metabolic process | negative regulation of signal transduction | positive regulation of developmental growth | regulation of dendritic spine development | signaling | positive regulation of growth | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | energy reserve metabolic process | regulation of developmental growth | positive regulation of cholangiocyte proliferation | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | anatomical structure morphogenesis | regulation of actin filament bundle assembly | positive regulation of plasma membrane bounded cell projection assembly | regulation of organ growth | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of phosphoprotein phosphatase activity | energy derivation by oxidation of organic compounds | kinase activity | developmental process | regulation of muscle cell differentiation | regulation of cell growth | peptidyl-serine phosphorylation | cellular protein modification process | positive regulation of oligodendrocyte differentiation | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of protein polymerization | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | regulation of lamellipodium assembly | response to organonitrogen compound | regulation of glycogen biosynthetic process | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | response to amino acid starvation | regulation of anion transport | positive regulation of nitric oxide biosynthetic process | central nervous system development | response to anesthetic | spinal cord development | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | positive regulation of neuron differentiation | positive regulation of lipid metabolic process | cardiac muscle contraction | regulation of cell projection organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to leucine starvation | cellular response to organic substance | regulation of cell death | positive regulation of cardiac muscle tissue development | regulation of smooth muscle cell proliferation | positive regulation of cell motility | regulation of translation | negative regulation of cell death | circulatory system development | aging | sexual reproduction | regulation of cellular component organization | regulation of cytoskeleton organization | muscle system process | positive regulation of signaling | positive regulation of myotube differentiation | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of glycogen metabolic process | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | organelle membrane | cell body | cell | organelle outer membrane | nuclear lumen | neuronal cell body | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear body | dendritic tree | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | PML body | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | vacuole | TORC2 complex | mitochondrion | TORC1 complex | lytic vacuole | Golgi membrane | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | lysosome | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular | lysosomal membrane | membrane | vacuolar membrane
