QuickView for MTRR (gene)

Gene Symbol:

MTRR Homo sapiens

Full name:

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Synonyms:

MSR, cblE, methionine synthase reductase, [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing), methionine synthase reductase, mitochondrial

Genomic Location:

Chr 5: 7922217-7954237

Description:

This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate m...

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This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCTGATA_MIR361

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-361

Cytogenetic Map:

5p15.31

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