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QuickView for MUL1 (gene)


Gene Symbol:
MUL1 Homo sapiens Homo sapiens
Full name:
mitochondrial E3 ubiquitin protein ligase 1
Synonyms:
C1orf166, GIDE, MAPL, MULAN, RNF218, mitochondrial ubiquitin ligase activator of NFKB 1, E3 SUMO-protein ligase MUL1, E3 ubiquitin ligase, E3 ubiquitin-protein ligase MUL1, RING-type E3 ubiquitin transferase NFKB 1, growth inhibition and death E3 ligase, mitochondria-anchored protein ligase, mitochondrial E3 ubiquitin ligase 1, mitochondrial ubiquitin ligase activator of NF-kB, mitochondrial-anchored protein ligase, putative NF-kappa-B-activating protein 266, ring finger protein 218
Genomic Location:
Chr 1: 20698530-20707241
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1p36.12


Transcripts Names
NM_024544
XM_011542137



GO Molecular Function

cation binding | enzyme binding | catalytic activity | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | identical protein binding | ion binding | protein binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | transferase activity | SUMO transferase activity | metal ion binding

GO Biological Process

regulation of JUN kinase activity | regulation of cysteine-type endopeptidase activity | negative regulation of immune system process | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | protein stabilization | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | regulation of mitochondrial fission | establishment of localization | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | nervous system development | negative regulation of mitochondrion organization | protein sumoylation | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | membrane organization | cellular process | response to exogenous dsRNA | localization | regulation of mitochondrial membrane potential | negative regulation of signaling | negative regulation of innate immune response | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | regulation of defense response to virus | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of cell differentiation | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | organelle localization | positive regulation of cellular protein metabolic process | negative regulation of chemokine (C-C motif) ligand 5 production | cellular component organization | MAPK cascade | regulation of mitochondrial fusion | positive regulation of autophagy of mitochondrion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | JNK cascade | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | response to stress | positive regulation of cysteine-type endopeptidase activity | programmed cell death | protein destabilization | regulation of dendrite extension | cellular localization | positive regulation of proteolysis | cellular response to organic cyclic compound | positive regulation of protein serine/threonine kinase activity | protein modification process | mitochondrion organization | macromolecule modification | activation of protein kinase activity | positive regulation of mitochondrion organization | stress-activated protein kinase signaling cascade | regulation of membrane potential | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | negative regulation of defense response to virus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | regulation of protein stability | positive regulation of neuron projection development | multicellular organism development | regulation of peptidase activity | regulation of MAPK cascade | positive regulation of protein sumoylation | phosphorus metabolic process | response to dsRNA | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of defense response to virus by host | regulation of neuron differentiation | negative regulation of chemokine production | regulation of mitochondrial membrane permeability | cellular response to stress | negative regulation of type I interferon-mediated signaling pathway | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | cellular response to exogenous dsRNA | mitochondrial transport | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | positive regulation of JNK cascade | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | positive regulation of hydrolase activity | positive regulation of cell differentiation | mitochondrion localization | negative regulation of protein kinase B signaling | stress-activated MAPK cascade | regulation of cellular protein metabolic process | negative regulation of immune response | phosphorylation | positive regulation of endopeptidase activity | regulation of apoptotic signaling pathway | protein phosphorylation | regulation of protein sumoylation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | regulation of mitochondrion organization | mitochondrial membrane organization | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | cellular response to dsRNA | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | negative regulation of cell growth | regulation of autophagy of mitochondrion | positive regulation of molecular function | activation of MAPK activity | protein metabolic process | negative regulation of mitochondrial fusion | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | protein ubiquitination | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | positive regulation of neurogenesis | negative regulation of response to cytokine stimulus | metabolic process | positive regulation of cell development | activation of cysteine-type endopeptidase activity involved in apoptotic process | ubiquitin-protein transferase activity | peptidyl-lysine modification | positive regulation of cell death | organic substance metabolic process | cell death | regulation of type I interferon-mediated signaling pathway | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | positive regulation of autophagy | regulation of JNK cascade | positive regulation of MAPK cascade | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of membrane permeability | response to mitochondrial depolarisation | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of growth | response to organic cyclic compound | regulation of developmental growth | positive regulation of mitochondrial fission | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | regulation of endopeptidase activity | positive regulation of MAP kinase activity | SUMO transferase activity | regulation of nervous system development | regulation of developmental process | developmental process | organelle organization | regulation of cell growth | cellular protein modification process | regulation of chemokine production | regulation of transport | negative regulation of cytokine-mediated signaling pathway | regulation of defense response to virus by host | positive regulation of dendrite extension | positive regulation of JUN kinase activity | positive regulation of metabolic process | positive regulation of neuron differentiation | mitochondrial fission | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of cell death | activation of JUN kinase activity | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of organelle membrane | integral component of membrane | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | organelle membrane | peroxisome | cell body | cell | organelle outer membrane | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | cell projection | mitochondrion | intrinsic component of mitochondrial outer membrane | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | axon | outer membrane | integral component of mitochondrial membrane | mitochondrial membrane | intracellular | integral component of mitochondrial outer membrane | membrane