QuickView for MUS81 (gene)

Gene Symbol:

MUS81 Homo sapiens

Full name:

MUS81 structure-specific endonuclease subunit

Synonyms:

SLX3, crossover junction endonuclease MUS81, MUS81 endonuclease homolog, SLX3 structure-specific endonuclease subunit homolog

Genomic Location:

Chr 11: 65384448-65390490

Description:

This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related es...

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This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRF_01 ,  SRF_Q6 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  ACTAYRNNNCCCR_UNKNOWN ,  WWTAAGGC_UNKNOWN ,  SRF_Q5_01 ,  SRF_C

Cytogenetic Map:

11q13.1

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