QuickView for MX1 (gene)
- Gene Symbol:
- MX1
Homo sapiens - Full name:
- MX dynamin like GTPase 1
- Synonyms:
- IFI-78K, IFI78, MX, MxA, interferon-induced GTP-binding protein Mx1, interferon-induced protein p78, interferon-inducible protein p78, interferon-regulated resistance GTP-binding protein MxA, myxoma resistance protein 1, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78
- Genomic Location:
- Chr 21: 41720024-41753008
- Description:
-
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and the...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
21q22.3
GO Molecular Function
guanyl ribonucleotide binding | ribonucleoside binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | cytoskeletal protein binding | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | microtubule binding | nucleoside binding | purine ribonucleotide binding | tubulin binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
response to virus | response to cytokine | cellular response to type I interferon | defense response to other organism | membrane fusion | defense response | membrane organization | cellular process | response to type I interferon | negative regulation of viral life cycle | regulation of cellular process | cellular component organization | response to stimulus | response to stress | programmed cell death | negative regulation of viral genome replication | cellular component assembly | mitochondrion organization | apoptotic process | response to external biotic stimulus | defense response to virus | membrane fission | cytokine-mediated signaling pathway | protein polymerization | negative regulation of viral process | cellular response to cytokine stimulus | cellular protein-containing complex assembly | cell communication | regulation of viral process | protein-containing complex assembly | response to organic substance | cell surface receptor signaling pathway | immune response | dynamin family protein polymerization involved in mitochondrial fission | cell death | type I interferon signaling pathway | signaling | response to biotic stimulus | organelle organization | innate immune response | mitochondrial fission | immune system process | regulation of viral genome replication | cellular response to organic substance | regulation of viral life cycle | response to other organism | signal transduction
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | nuclear envelope | perinuclear region of cytoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | mitochondrial membrane | cytosol | intracellular | membrane
