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QuickView for MYC (gene)


Gene Symbol:
MYC Homo sapiens Homo sapiens
Full name:
MYC proto-oncogene, bHLH transcription factor
Synonyms:
MRTL, MYCC, bHLHe39, c-Myc, myc proto-oncogene protein, avian myelocytomatosis viral oncogene homolog, class E basic helix-loop-helix protein 39, myc-related translation/localization regulatory factor, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog
Genomic Location:
Chr 8: 128817498-128822856
Description:
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amp...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 8
8q24.21





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | repressing transcription factor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | protein-containing complex binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | activating transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | negative regulation of phosphorylation | Notch signaling pathway | positive regulation of cell proliferation involved in kidney development | response to radiation | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | negative regulation of cell division | regulation of cysteine-type endopeptidase activity | negative regulation of MAPK cascade | negative regulation of immune system process | regulation of monocyte differentiation | response to cytokine | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | morphogenesis of an epithelium | regulation of programmed cell death | establishment of localization | regulation of immune system process | fibroblast apoptotic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | response to drug | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | cellular chemical homeostasis | regulation of organelle organization | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | localization | cellular homeostasis | epithelial tube morphogenesis | chromatin organization | protein-DNA complex disassembly | negative regulation of signaling | canonical Wnt signaling pathway | positive regulation of metanephric cap mesenchymal cell proliferation | positive regulation of telomerase activity | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | response to hypoxia | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | positive regulation of response to DNA damage stimulus | protein deubiquitination | MAPK cascade | regulation of cell division | urogenital system development | nephron tubule morphogenesis | response to UV | response to stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | cellular response to light stimulus | cellular response to hypoxia | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | positive regulation of cysteine-type endopeptidase activity | beta-catenin-TCF complex assembly | programmed cell death | positive regulation of proteolysis | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | negative regulation of hemopoiesis | protein modification process | cellular biosynthetic process | kidney development | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | response to light stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | ureteric bud development | Wnt signaling pathway | negative regulation of phosphate metabolic process | multicellular organism development | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | regulation of phosphorylation | kidney morphogenesis | regulation of gene expression | kidney epithelium development | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | regulation of telomerase activity | cellular ion homeostasis | cellular response to radiation | animal organ morphogenesis | negative regulation of myeloid cell differentiation | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | mesonephric epithelium development | positive regulation of endopeptidase activity | negative regulation of stress-activated MAPK cascade | mitotic cell cycle phase transition | protein phosphorylation | response to gamma radiation | mesonephros development | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | cellular response to UV | oxygen transport | cellular response to drug | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | chromatin remodeling | renal tubule development | positive regulation of DNA biosynthetic process | regulation of protein metabolic process | homeostatic process | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | iron ion homeostasis | regulation of RNA metabolic process | renal system development | nephron development | positive regulation of molecular function | protein-containing complex assembly | ureteric bud morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of fibroblast proliferation | DNA-binding transcription factor activity | response to organic substance | tissue morphogenesis | regulation of hemopoiesis | cell cycle arrest | branching morphogenesis of an epithelial tube | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | oxidation-reduction process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | chemical homeostasis | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | negative regulation of cellular protein metabolic process | gene expression | positive regulation of programmed cell death | ion homeostasis | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | regulation of chromosome organization | cellular iron ion homeostasis | transcription, DNA-templated | drug transport | morphogenesis of a branching epithelium | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | energy reserve metabolic process | regulation of epithelial cell proliferation | protein-containing complex disassembly | negative regulation of fibroblast proliferation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | negative regulation of monocyte differentiation | regulation of developmental process | positive regulation of DNA metabolic process | energy derivation by oxidation of organic compounds | regulation of mesenchymal cell proliferation | developmental process | organelle organization | regulation of DNA biosynthetic process | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of mesenchymal cell proliferation | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | cellular metal ion homeostasis | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | transition metal ion homeostasis | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | nephron tubule development | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular