QuickView for MYCN (gene)

Gene Symbol:

MYCN Homo sapiens

Full name:

MYCN proto-oncogene, bHLH transcription factor

Synonyms:

MODED, N-myc, NMYC, ODED, bHLHe37, N-myc proto-oncogene protein, class E basic helix-loop-helix protein 37, neuroblastoma MYC oncogene, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene, oncogene NMYC, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog

Genomic Location:

Chr 2: 15998134-16004580

Description:

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript ...

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This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  GTGTTGA_MIR505 ,  TGGNNNNNNKCCAR_UNKNOWN ,  TTTTGAG_MIR373 ,  CTTTGCA_MIR527 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  GTACTGT_MIR101 ,  ACTTTAT_MIR1425P ,  ZIC3_01 ,  GGGAGGRR_MAZ_Q6 ,  ATGCTGG_MIR338 ,  ATACCTC_MIR202 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  AP2_Q3 ,  CAGTCAC_MIR134 ,  AP4_Q6_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  ZIC2_01 ,  GTGGGTGK_UNKNOWN ,  GGCCAGT_MIR193A_MIR193B ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-543

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miRNA binding sites
(Source: miRecords):

hsa-miR-34a Targeted Genes ,  hsa-miR-101 Targeted Genes

Cytogenetic Map:

2p24.3

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