QuickView for Maf (gene)

Gene Symbol:

MAF Homo sapiens

Full name:

MAF bZIP transcription factor

Synonyms:

AYGRP, CCA4, CTRCT21, c-MAF, transcription factor Maf, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene, T lymphocyte c-maf long form, c-maf proto-oncogene, proto-oncogene c-Maf, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

Genomic Location:

Chr 16: 78185732-78192112

Description:

The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including e...

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The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Gallus gallus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  HNF3ALPHA_Q6 ,  MCAATNNNNNGCG_UNKNOWN ,  OCT1_B ,  TAL1ALPHAE47_01 ,  TCANNTGAY_SREBP1_01 ,  CREBP1CJUN_01 ,  ZIC1_01 ,  FOXJ2_02 ,  P53_DECAMER_Q2 ,  HFH3_01 ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  TTTTGAG_MIR373 ,  ZF5_01 ,  GTGACTT_MIR224 ,  ATF4_Q2 ,  AACTGGA_MIR145 ,  WGTTNNNNNAAA_UNKNOWN ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ZIC3_01 ,  GTGCAAA_MIR507 ,  CREB_Q4 ,  MYAATNNNNNNNGGC_UNKNOWN ,  WTGAAAT_UNKNOWN ,  TGAYRTCA_ATF3_Q6 ,  HNF4_01 ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  TFIII_Q6 ,  ATGCTGG_MIR338 ,  GTGACGY_E4F1_Q6 ,  P53_02 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TATA_C ,  ACCAAAG_MIR9 ,  ATGTTAA_MIR302C ,  E4F1_Q6 ,  AHR_Q5 ,  CTTTAAR_UNKNOWN ,  AP2_Q3 ,  SOX5_01 ,  GACTGTT_MIR212_MIR132 ,  OCT1_06 ,  AATGTGA_MIR23A_MIR23B ,  TTGCCAA_MIR182 ,  POU3F2_02 ,  YGCGYRCGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  ATATGCA_MIR448 ,  ARGGGTTAA_UNKNOWN ,  GATA1_05 ,  GTTATAT_MIR410 ,  CREB_Q2 ,  PAX5_01 ,  SREBP_Q3 ,  ATAACCT_MIR154 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  TGACGTCA_ATF3_Q6 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  TCATCTC_MIR143 ,  CREB_01 ,  PAX4_01

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Cytogenetic Map:

16q23.2

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