QuickView for Matrix Gla protein (gene)

Gene Symbol:

MGP Homo sapiens

Full name:

matrix Gla protein

Synonyms:

GIG36, MGLAP, NTI, matrix Gla protein, cell growth-inhibiting gene 36 protein

Genomic Location:

Chr 12: 14926094-14930095

Description:

This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature...

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This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  WGTTNNNNNAAA_UNKNOWN ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  TGTTTGY_HNF3_Q6 ,  TGTYNNNNNRGCARM_UNKNOWN ,  RNGTGGGC_UNKNOWN

Cytogenetic Map:

12p12.3

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