QuickView for Mcl-1 (gene)

Gene Symbol:

MCL1 Homo sapiens

Full name:

MCL1, BCL2 family apoptosis regulator

Synonyms:

BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, induced myeloid leukemia cell differentiation protein Mcl-1, BCL2 family apoptosis regulator, bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1 (BCL2-related)

Genomic Location:

Chr 1: 148813658-148818760

Description:

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing...

View Full Description

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CTATGCA_MIR153 ,  TACTTGA_MIR26A_MIR26B ,  ATGTACA_MIR493 ,  ACTTTAT_MIR1425P ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  CTCAGGG_MIR125B_MIR125A ,  CAGCTTT_MIR320 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  SRF_Q4 ,  SCGGAAGY_ELK1_02 ,  GGCCAGT_MIR193A_MIR193B

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-504

View More

View Less

miRNA binding sites
(Source: miRecords):

hsa-miR-29b Targeted Genes ,  hsa-miR-15a/hsa-miR-16 Targeted Genes ,  hsa-miR-193a-3p Targeted Genes

Cytogenetic Map:

1q21.2

search → result