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QuickView for Mdm2 (gene)


Gene Symbol:
MDM2 Homo sapiens Homo sapiens
Full name:
MDM2 proto-oncogene
Synonyms:
ACTFS, HDMX, hdm2, E3 ubiquitin-protein ligase Mdm2, MDM2 oncogene, E3 ubiquitin protein ligase, MDM2 proto-oncogene, E3 ubiquitin protein ligase, Mdm2, p53 E3 ubiquitin protein ligase homolog, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, double minute 2, human homolog of; p53-binding protein, oncoprotein Mdm2
Genomic Location:
Chr 12: 67488247-67520481
Description:
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a p...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q15





GO Molecular Function

NEDD8 transferase activity | cation binding | enzyme binding | nucleic acid binding | protein-containing complex binding | disordered domain specific binding | signaling receptor binding | 5S rRNA binding | ubiquitin binding | receptor serine/threonine kinase binding | catalytic activity | ribonucleoprotein complex binding | protein domain specific binding | protein N-terminus binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | p53 binding | identical protein binding | ubiquitin protein ligase activity | ubiquitin-like protein binding | scaffold protein binding | ion binding | organic cyclic compound binding | protein binding | zinc ion binding | ubiquitin protein ligase binding | NEDD8 ligase activity | ligase activity | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | ubiquitin-like protein ligase activity | SUMO transferase activity | metal ion binding | heterocyclic compound binding | rRNA binding | peroxisome proliferator activated receptor binding | RNA binding

GO Biological Process

protein modification by small protein removal | positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | response to radiation | regulation of cell cycle process | cellular response to decreased oxygen levels | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | response to nutrient levels | regulation of neurogenesis | regulation of cellular localization | intracellular signal transduction | proteolysis | regulation of cell development | regulation of localization | regulation of cell cycle G1/S phase transition | response to isoquinoline alkaloid | positive regulation of G1/S transition of mitotic cell cycle | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of cysteine-type endopeptidase activity | response to immobilization stress | establishment of localization | response to hormone | negative regulation of cellular process | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | nervous system development | cellular response to extracellular stimulus | positive regulation of protein catabolic process | response to drug | protein sumoylation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of cellular component movement | generation of neurons | response to antibiotic | mesenchyme development | negative regulation of proteolysis | positive regulation of vascular smooth muscle cell proliferation | response to formaldehyde | cellular process | organic substance catabolic process | response to morphine | response to magnesium ion | regulation of cell motility | localization | proteolysis involved in cellular protein catabolic process | mitotic DNA integrity checkpoint | regulation of DNA damage response, signal transduction by p53 class mediator | tissue remodeling | heart morphogenesis | negative regulation of signaling | negative regulation of G1/S transition of mitotic cell cycle | positive regulation of protein export from nucleus | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | negative regulation of cell cycle arrest | response to inorganic substance | regulation of protein export from nucleus | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of apoptotic signaling pathway | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | positive regulation of cell cycle phase transition | response to ether | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | protein deubiquitination | cellular response to vitamin B1 | response to UV | positive regulation of cellular protein catabolic process | response to stimulus | vasculature development | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | blood vessel remodeling | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to cocaine | cellular response to light stimulus | cellular response to hypoxia | response to stress | cellular response to vitamin | positive regulation of cellular protein localization | regulation of cell proliferation | negative regulation of neuron projection development | regulation of blood circulation | response to peptide | protein localization to nucleus | regulation of cell cycle phase transition | response to actinomycin D | regulation of smooth muscle cell migration | protein destabilization | supramolecular fiber organization | positive regulation of proteolysis involved in cellular protein catabolic process | regulation of heart rate | cellular protein catabolic process | atrioventricular valve morphogenesis | cellular localization | cardiovascular system development | positive regulation of proteolysis | cellular response to toxic substance | proteasomal protein catabolic process | cellular response to organic cyclic compound | regulation of protein transport | negative regulation of metabolic process | cellular component assembly | protein modification process | regulation of protein processing | regulation of peptide transport | response to iron ion | macromolecule modification | cellular response to UV-C | regulation of intracellular transport | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | blood vessel development | positive regulation of vascular associated smooth muscle cell migration | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | cellular response to actinomycin D | cellular response to hormone stimulus | response to light stimulus | endocardial cushion development | transcription factor catabolic process | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | regulation of protein stability | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of peptidase activity | positive regulation of smooth muscle cell migration | cellular response to DNA damage stimulus | regulation of catalytic activity | cellular response to oxidative stress | regulation of intrinsic apoptotic signaling pathway | amyloid fibril formation | negative regulation of peptidase activity | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | response to lipid | cellular response to peptide | cell cycle | protein catabolic process | endocardial cushion morphogenesis | positive regulation of intracellular protein transport | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | cellular response to radiation | animal organ morphogenesis | response to ammonium ion | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | negative regulation of signal transduction by p53 class mediator | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cardiac atrium development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | cellular response to alkaloid | cellular response to gamma radiation | response to oxidative stress | ubiquitin protein ligase activity | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | protein localization to organelle | positive regulation of cell migration | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | mesenchyme morphogenesis | cardiac septum morphogenesis | response to vitamin B1 | response to toxic substance | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | response to xenobiotic stimulus | regulation of heart contraction | positive regulation of cell cycle G1/S phase transition | response to gamma radiation | cellular response to UV | cellular response to drug | mitotic G1 DNA damage checkpoint | response to estrogen | cell communication | regulation of cellular metabolic process | cellular response to estrogen stimulus | negative regulation of protein processing | regulation of protein metabolic process | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | viral process | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | regulation of nucleocytoplasmic transport | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of cell cycle arrest | response to water-immersion restraint stress | protein-containing complex assembly | heart valve development | ventricular septum development | protein metabolic process | cellular response to nutrient | regulation of establishment of protein localization | cardiac ventricle development | response to organic substance | negative regulation of cell projection organization | protein ubiquitination | G1 DNA damage checkpoint | tissue morphogenesis | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | protein autoubiquitination | anatomical structure development | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of mitotic cell cycle | cellular protein localization | peptidyl-lysine modification | cellular response to hydrogen peroxide | regulation of response to DNA damage stimulus | cellular response to reactive oxygen species | heart valve morphogenesis | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | negative regulation of neuron differentiation | negative regulation of cellular protein metabolic process | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | cellular response to ionizing radiation | response to alkaloid | establishment of protein localization | atrioventricular valve development | positive regulation of intracellular transport | atrial septum development | positive regulation of protein transport | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | response to UV-C | protein localization | cellular protein metabolic process | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | SUMO transferase activity | signal transduction involved in DNA damage checkpoint | regulation of nervous system development | regulation of developmental process | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | traversing start control point of mitotic cell cycle | positive regulation of cell cycle process | cardiac septum development | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | regulation of transport | response to organonitrogen compound | cardiac chamber development | negative regulation of hydrolase activity | signal transduction involved in mitotic G1 DNA damage checkpoint | response to anesthetic | positive regulation of metabolic process | regulation of cell projection organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to steroid hormone | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | negative regulation of cell development | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | positive regulation of nucleocytoplasmic transport | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | synapse | endocytic vesicle membrane | organelle membrane | cytoplasmic vesicle | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | plasma membrane | vesicle | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cell periphery | membrane-enclosed lumen | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane