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QuickView for Meclizine (compound)


PubChem
Name: Meclizine
PubChem Compound ID: 165690
Description: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
Molecular formula: C31H34Cl3N3O2
Molecular weight: 586.979 g/mol
Synonyms:
3-Pyridinecarboxylic acid, mixt. with 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine dihydrochloride; Antivert; 8064-07-1
DrugBank
Identification
Name: Meclizine
Name (isomeric): DB00737
Drug Type: small molecule
Description: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
Brand: Parachloramine, Meclizine Hcl, Monamine, Neo-Istafene, Antivert/25, Sabari, Ravelon, Bonadoxin, Travelon, Neo-Suprimal, Navicalm, Histametizyne, Sea-Legs, Neo-Suprimel, Diadril, Marex, Vomissels, Subari, Bonamine, Dramamine II, Antivert/50, Dramamine, Antivert, Meclozine, Chiclida, Medivert, Veritab, Suprimal, Ancolan, Itinerol, Siguran, Bonine, Vomisseis, Bonadettes, Histamethizine, Ancolon, Histamethine, Postafene, Histametizine, Peremesin, Calmonal, Meclicot
Brand name mixture: Antivert Tab(Meclizine Hydrochloride + Nicotinic Acid)
Category: Antihistamines, Histamine H1 Antagonists, Antiemetics, Anti-Allergic Agents
CAS number: 569-65-3
Pharmacology
Indication: For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Pharmacology: Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mechanism of Action: Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Absorption: Well absorbed
Biotransformation: Hepatic
Half Life: 6 hours
Toxicity: Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce irritation. Avoid alcohol.
Drug interaction:
DonepezilPossible antagonism of action
TrimethobenzamideTrimethobenzamide and Meclizine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TacrineThe therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Meclizine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
RivastigminePossible antagonism of action
TriprolidineTriprolidine and Meclizine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
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