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QuickView for Meclizine (compound)
PubChem
| Name: | Meclizine |
|---|---|
| PubChem Compound ID: | 165690 |
| Description: | A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. |
| Molecular formula: | C31H34Cl3N3O2 |
| Molecular weight: | 586.979 g/mol |
| Synonyms: |
3-Pyridinecarboxylic acid, mixt. with 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine dihydrochloride; Antivert; 8064-07-1
|
DrugBank
Identification
| Name: | Meclizine |
|---|---|
| Name (isomeric): | DB00737 |
| Drug Type: | small molecule |
| Description: | A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. |
| Brand: | Parachloramine, Meclizine Hcl, Monamine, Neo-Istafene, Antivert/25, Sabari, Ravelon, Bonadoxin, Travelon, Neo-Suprimal, Navicalm, Histametizyne, Sea-Legs, Neo-Suprimel, Diadril, Marex, Vomissels, Subari, Bonamine, Dramamine II, Antivert/50, Dramamine, Antivert, Meclozine, Chiclida, Medivert, Veritab, Suprimal, Ancolan, Itinerol, Siguran, Bonine, Vomisseis, Bonadettes, Histamethizine, Ancolon, Histamethine, Postafene, Histametizine, Peremesin, Calmonal, Meclicot |
| Brand name mixture: | Antivert Tab(Meclizine Hydrochloride + Nicotinic Acid) |
| Category: | Antihistamines, Histamine H1 Antagonists, Antiemetics, Anti-Allergic Agents |
| CAS number: | 569-65-3 |
Pharmacology
| Indication: | For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness. |
|---|---|
| Pharmacology: | Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus. |
| Mechanism of Action: | Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone. |
| Absorption: | Well absorbed |
| Biotransformation: | Hepatic |
| Half Life: | 6 hours |
| Toxicity: | Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat). |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Enzymes
