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QuickView for Mecp2 (gene)


Gene Symbol:
MECP2 Homo sapiens Homo sapiens
Full name:
methyl-CpG binding protein 2
Synonyms:
AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG-binding protein 2, meCp-2 protein, testis tissue sperm-binding protein Li 41a
Genomic Location:
Chr X: 152940458-153016323
Description:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding s...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 GATTGGY_NFY_Q6_01 TTTGCAC_MIR19A_MIR19B GTGTTGA_MIR505 TGANTCA_AP1_C ACACTCC_MIR122A GCATTTG_MIR105 TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D GATA3_01 E4BP4_01
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for let-7 Predicted Gene Targets for miR-103 Predicted Gene Targets for miR-122a Predicted Gene Targets for miR-129 Predicted Gene Targets for miR-130 Predicted Gene Targets for miR-132 Predicted Gene Targets for miR-148 Predicted Gene Targets for miR-181 Predicted Gene Targets for miR-19 Predicted Gene Targets for miR-192
Cytogenetic Map:
chr X
Xq28





GO Molecular Function

sequence-specific DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | nucleic acid binding | mRNA binding | nucleotide binding | chromatin binding | protein domain specific binding | protein N-terminus binding | DNA binding | transcription corepressor activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | siRNA binding | organic cyclic compound binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded methylated DNA binding | methyl-CpG binding | transcription coregulator activity | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | positive regulation of DNA methylation | brain development | regulation of supramolecular fiber organization | respiratory gaseous exchange | purine ribonucleotide metabolic process | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | microtubule cytoskeleton organization involved in mitosis | regulation of microtubule polymerization or depolymerization | long-term memory | positive regulation of cellular component organization | behavioral fear response | regulation of synapse assembly | regulation of localization | positive regulation of histone H3-K9 methylation | regulation of programmed cell death | peptidyl-amino acid modification | phosphatidylglycerol metabolic process | inositol metabolic process | smooth muscle cell differentiation | establishment of localization | regulation of DNA methylation | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | social behavior | negative regulation of RNA biosynthetic process | histone modification | microtubule cytoskeleton organization | cell differentiation | excitatory postsynaptic potential | defense response | nervous system development | generation of precursor metabolites and energy | neurogenesis | polyol metabolic process | regulation of organelle organization | generation of neurons | phospholipid metabolic process | microtubule-based process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | secretion | positive regulation of microtubule polymerization | regulation of histone H3-K9 trimethylation | regulation of cell motility | localization | chromatin organization | positive regulation of synaptic transmission | regulation of respiratory gaseous exchange | cell maturation | nucleotide metabolic process | visual learning | chemical synaptic transmission | neuron development | synapse assembly | ATP synthesis coupled electron transport | regulation of histone H3-K9 methylation | cellular respiration | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | learning | macromolecule localization | regulation of histone modification | negative regulation of apoptotic process | response to hypoxia | nucleoside triphosphate metabolic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | ribonucleotide metabolic process | negative regulation of peptidyl-lysine acetylation | negative regulation of cellular metabolic process | regulation of cell differentiation | interspecies interaction between organisms | muscle structure development | muscle cell differentiation | negative regulation of histone methylation | negative regulation of cell motility | cellular amino acid metabolic process | cellular biogenic amine metabolic process | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | gene silencing | regulation of metabolic process | regulation of protein complex assembly | neurological system process involved in regulation of systemic arterial blood pressure | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | cellular lipid metabolic process | regulation of respiratory gaseous exchange by neurological system process | ventricular system development | head development | associative learning | regulation of histone methylation | regulation of vasculature development | response to stimulus | purine nucleotide metabolic process | regulation of mitotic cell cycle phase transition | genetic imprinting | metencephalon development | positive regulation of protein metabolic process | mitotic spindle organization | response to stress | cellular nitrogen compound biosynthetic process | alcohol metabolic process | regulation of cell proliferation | electron transport chain | negative regulation of angiogenesis | regulation of cell cycle phase transition | secretion by cell | organic hydroxy compound transport | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | blood circulation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | pathogenesis | protein modification process | regulation of synapse structure or activity | amine metabolic process | modulation of chemical synaptic transmission | cellular biosynthetic process | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | regulation of membrane potential | organic hydroxy compound metabolic process | negative regulation of neuron apoptotic process | regulation of cell cycle G2/M phase transition | response to light stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | positive regulation of organelle organization | multicellular organism development | protein acetylation | histone methylation | phosphorus metabolic process | neuromuscular process controlling posture | learning or memory | cerebellum development | lipid metabolic process | regulation of hormone levels | positive regulation of chromosome organization | proprioception | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of postsynaptic membrane potential | methylation | regulation of microtubule nucleation | organic substance transport | nervous system process | cell cycle | regulation of blood pressure | synaptic signaling | organophosphate metabolic process | positive regulation of microtubule nucleation | regulation of systemic arterial blood pressure | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of smooth muscle cell differentiation | adult locomotory behavior | regulation of synapse organization | regulation of nitrogen compound metabolic process | regulation of cell migration | cardiolipin metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | positive regulation of protein complex assembly | transcription corepressor activity | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cell cycle G2/M phase transition | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | synapse organization | regulation of endothelial cell migration | nucleobase-containing small molecule metabolic process | cognition | negative regulation of smooth muscle cell differentiation | histone acetylation | internal peptidyl-lysine acetylation | negative regulation of epithelial cell migration | biosynthetic process | locomotory behavior | sensory perception of pain | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | hindbrain development | phosphorylation | carbohydrate metabolic process | startle response | post-embryonic development | phosphate-containing compound metabolic process | negative regulation of blood vessel endothelial cell migration | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of respiratory system process | mitochondrial ATP synthesis coupled electron transport | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of synapse assembly | regulation of mitotic cell cycle | regulation of microtubule-based process | drug metabolic process | carboxylic acid metabolic process | neuron maturation | neuron differentiation | regulation of gene expression by genetic imprinting | multicellular organismal response to stress | fear response | protein metabolic process | DNA-binding transcription factor activity | positive regulation of protein modification process | visual behavior | positive regulation of histone H3-K9 trimethylation | anatomical structure development | positive regulation of mitotic cell cycle phase transition | glutamine metabolic process | mitotic cell cycle | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | regulation of RNA biosynthetic process | developmental maturation | oxidation-reduction process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of histone acetylation | peptidyl-lysine modification | behavior | oxidative phosphorylation | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | negative regulation of cellular component movement | phosphatidylcholine metabolic process | cytoskeleton organization | regulation of chromosome organization | catecholamine secretion | transcription, DNA-templated | memory | adult behavior | negative regulation of protein metabolic process | sensory perception | regulation of epithelial cell migration | steroid metabolic process | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of chromosome organization | signaling | covalent chromatin modification | glucocorticoid metabolic process | regulation of transcription, DNA-templated | neuromuscular process | cell development | internal protein amino acid acetylation | protein localization | organic acid metabolic process | cellular protein metabolic process | hormone metabolic process | cellular macromolecule biosynthetic process | protein methylation | dendrite development | regulation of nervous system development | regulation of developmental process | glycerophospholipid metabolic process | positive regulation of DNA metabolic process | energy derivation by oxidation of organic compounds | developmental process | organelle organization | regulation of muscle cell differentiation | behavioral defense response | positive regulation of cell cycle process | cellular protein modification process | monoamine transport | mitochondrial electron transport, ubiquinol to cytochrome c | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | positive regulation of transcription, DNA-templated | positive regulation of protein polymerization | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | negative regulation of protein acetylation | transcription coregulator activity | heterocycle metabolic process | central nervous system development | negative regulation of muscle cell differentiation | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | positive regulation of metabolic process | chromosome organization | regulation of synaptic plasticity | chromatin silencing | positive regulation of histone methylation | cellular metabolic process | long-term synaptic potentiation | ATP metabolic process | regulation of cell death | negative regulation of cell death | spindle organization | negative regulation of locomotion | regulation of microtubule cytoskeleton organization | negative regulation of cell differentiation | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | respiratory electron transport chain | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | synapse | microtubule organizing center | cell | cytoplasm | intracellular organelle | centrosome | protein-containing complex | postsynapse | chromatin | microtubule cytoskeleton | mitochondrion | extracellular region | gamma-tubulin complex | membrane-bounded organelle | heterochromatin | nucleus | organelle | extracellular space | cytosol | cytoskeleton | intracellular